Bee Sting-Inspired Inflammation-Responsive Microneedles for Periodontal Disease Treatment  

作　　者：Chuanhui Song Xiaoxuan Zhang Minhui Lu Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,Institute of Translational Medicine,The Affliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210002,China [2]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [3]Chemistry and Biomedicine Innovation Center,Nanjing University,Nanjing 210023 China

出　　处：《Research》2023年第4期23-31,共9页研究（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060 and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);the Project funded by the China Postdoctoral Science Foundation(2021-TQ0145);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB690),the Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038)。

摘　　要：Periodontal lesions are common and frustrating diseases that impact life quality.Efforts in this aspect aim at developing local drug delivery systems with better efficacy and less toxicity.Herein,inspired by the sting separation behavior of bees,we conduct novel reactive oxygen species(ROS)-responsive detachable microneedles(MNs)that carry antibiotic metronidazole(Met)for controllable periodontal drug delivery and periodontitis treatment.Benefiting from the needle-base separation ability,such MNs can penetrate through the healthy gingival to reach the gingival sulcus's bottom while offering minimal impact to oral function.Besides,as the drug-encapsulated cores were protected by poly(lactic-co-glycolic acid)(PLGA)shells in MNs,the surrounding normal gingival tissue is not affected by Met,resulting in excellent local biosafety.Additionally,with the ROS-responsive PLGA-thioketal-polyethylene glycol MN tips,they can be unlocked to release Met directly around the pathogen under the high ROS in the periodontitis sulcus,bringing about improved therapeutic effects.Based on these characteristics,the proposed bioinspired MNs show good therapeutic results in treating a rat model with periodontitis,implying their potential in periodontal disease.

关 键 词：NEEDLE SEPARATION bringing 

分 类 号：R781.4[医药卫生—口腔医学]