基于超声导波反演参数定征皮质骨骨质状况研究  

Study of cortical bone characterization based on the parameters inversed by ultrasonic guided waves

作　　者：盛帆 宋小军 樊天地[3] 张璠 李义方 SHENG Fan;SONG Xiaojun;FAN Tiandi;ZHANG Fan;LI Yifang(College of Electronics and Information Engineering,Shanghai University of Electric Power,Shanghai 201300,China;Center for Biomedical Engineering,Fudan University,Shanghai 200433,China;State Grid Anhui Electric Power Company Limited Ultra High Voltage Branch,Hefei 230000,Anhui,China;Academy for Engineering and Technology,Fudan University,Shanghai 200433,China)

机构地区：[1]上海电力大学电子与信息工程学院,上海201300 [2]复旦大学生物医学工程中心,上海200433 [3]国网安徽省电力有限公司超高压分公司,安徽合肥230000 [4]复旦大学工程与应用技术研究院,上海200433

出　　处：《声学技术》2023年第6期778-784,共7页Technical Acoustics

基　　金：博士后面上基金项目(2019M661334)资助。

摘　　要：骨质疏松发生时,人体皮质骨层的孔隙度将增大。为研究皮质骨参数(厚度、横波速度、纵波速度)与骨质疏松症的关系,文章利用有限元方法对不同孔隙度(0∶3%∶27%)的单层皮质骨进行仿真,以3个周期的高斯包络正弦波作为激励,将采集到的超声导波信号先后经过二维傅里叶变换和Burg算法处理后得到频散数据,与基于FloquetBloch理论建立的理论频散曲线数据库进行匹配反演,得到皮质骨厚度、横波速度、纵波速度参数。结果显示皮质骨厚度反演准确,皮质骨孔隙度与横波速度和纵波速度呈负相关,横波速度敏感度为19.0%,纵波速度敏感度为5.5%。横波速度敏感度更高,临床诊断潜力更大。并对6组牛胫骨进行了离体实验,结果显示,反演得到的皮质骨厚度与其实际测量值的平均相对误差为4.0%,且实验频散曲线与理论频散曲线相吻合,验证了文中算法在真实皮质骨参数反演上的可行性和准确性。文中的研究在骨质疏松超声检测中具有应用潜力。The porosity of human cortical bone will increase when osteoporosis occurs.To study the relationship between cortical bone parameters(thickness,transverse wave velocity,longitudinal wave velocity)and osteoporosis,the finite element method is used to simulate the cortical bone with different porosities(0∶3%∶27%)in this paper.By using a 3-period Gaussian envelope sine wave as excitation,the acquired ultrasound guided wave signals are processed by the two-dimensional Fourier transform and Burg algorithm to get the experimental dispersion trajectories,and then by grid searching to match them with the theoretical dispersion database established by the Floquet-Bloch theory to get the cortical thickness,transverse velocity,and longitudinal velocity.The results show that the cortical bone thickness inversion is accurate,and the cortical bone porosity is negatively correlated with the transverse and longitudinal velocities.The transverse velocity sensitivity is 19.0%and the longitudinal velocity sensitivity is 5.5%,which indicates that the transverse velocity is more sensitive to the porosity and has greater clinical diagnostic potential for osteoporosis.Experimental signals are also collected from six bovine cortical bone plates.The inversion results show that average relative error of the cortical thicknesses is 4%,and the experimental dispersion trajectories match well with the theoretical dispersion curves,therefore the feasibility and accuracy of the proposed inversion algorithm in this paper is verified.The research in this paper has application potential for ultrasonic detection of osteoporosis.

关 键 词：超声导波 皮质骨 参数反演 骨质疏松 频散曲线 

分 类 号：TB559[理学—物理]