肺癌患者血清Pokemon、AGR2表达水平变化及其临床意义  

Serum Levels of Pokemon and AGR2 in Patients With Lung Cancer and Their Clinical Significance

作　　者：王小倩[1] 邬德东 张倩[1] WANG Xiaoqian;WU Dedong;ZHANG Qian(Zhengzhou First People's Hospital,Zhengzhou,450000)

机构地区：[1]河南省郑州市第一人民医院,450000

出　　处：《实用癌症杂志》2024年第1期46-50,共5页The Practical Journal of Cancer

摘　　要：目的探讨肺癌患者血清Pokemon、AGR2表达水平变化及其临床意义。方法收集NSCLC患者85例纳入NSCLC组,同时期收集体检正常85例纳入对照组。对比两组血清Pokemon、AGR2表达水平,及影响NSCLC患者血清Pokemon、AGR2表达因素,采用受试者工作特征(Receiver Operating Characteristic,ROC)曲线预测最佳临界值,对比不同血清Pokemon、AGR2表达患者疗效,并分析影响患者预后独立危险因素。结果NSCLC组血清Pokemon[(189.68±91.13)ng/ml]、AGR2[(15.62±5.22)ng/ml]水平均显著高于对照组(t=16.792,P<0.001;t=20.439,P<0.001)。肿瘤直径、TNM分期均为影响NSCLC预后的因素,P<0.05,性别、年龄、吸烟史、组织学类型、分化程度及淋巴结转移并不是影响NSCLC患者预后的影响因素,P>0.05。肿瘤直径≥5 cm、TNM分期Ⅳ期均为影响血清Pokemon、AGR2水平的因素。血清Pokemon水平AUC=0.832(95%CI:0.674~0.988),血清AGR2水平AUC=0.814(95%CI:0.651~0.954)。Pokemon<135.08 ng/ml组和AGR2<15.52 ng/ml组患者治疗总有效率均显著高于Pokemon≥135.08 ng/ml组、AGR2≥15.52 ng/ml组(χ^(2)=6.079,P=0.014;χ^(2)=7.774,P=0.005)。淋巴结转移、Pokemon≥135.08 ng/ml、AGR2≥15.52 ng/ml均是影响NSCLC患者生存的独立危险因素,P<0.05。结论晚期NSCLC患者血清Pokemon、AGR2表达水平上升,均可作为化疗疗效及预后评估指标。Objective To investigate the expression levels of serum Pokemon and AGR2 in patients with lung cancer and their clinical significance.Methods 85 patients with NSCLC were included in the NSCLC group,and 85 patients with normal physical examination were included in the control group.After compared the expression levels of serum Pokemon and AGR2 between the 2 groups and the factors affecting the expression of serum Pokemon and AGR2 in NSCLC patients,Receiver Operating Characteristic(ROC)curve was used to predict the optimal critical value.The efficacy of patients with different serum Pokemon and AGR2 expression was compared,and the independent risk factors affecting the prognosis of patients were analyzed.Results The levels of serum Pokemon[(189.68±91.13)ng/ml]and AGR2[(15.62±5.22)ng/ml]in NSCLC group were significantly higher than those in control group(t=16.792,P<0.001;t=20.439,P<0.001).Tumor diameter and TNM stage were the prognostic factors of NSCLC(P<0.05).Gender,age,smoking history,histological type,differentiation degree and lymph node metastasis were not the prognostic factors of NSCLC patients(P>0.05).Tumor diameter≥5cm and TNM stageⅣwere the factors affecting serum Pokemon and AGR2 levels.Serum Pokemon level AUC=0.832(95%CI:0.674~0.988),serum AGR2 level AUC=0.814(95%CI:0.651~0.954).The total effective rate of treatment in Pokemon<135.08 ng/ml and AGR2<15.52 ng/ml groups was significantly higher than that in Pokemon≥135.08 ng/ml and AGR2≥15.52 ng/ml groups(χ^(2)=6.079,P=0.014;χ^(2)=7.774,P=0.005).Lymph node metastasis,Pokemon≥135.08 ng/ml,AGR2≥15.52 ng/ml were all independent risk factors affecting the survival of NSCLC patients,P<0.05.Conclusion The expression levels of serum Pokemon and AGR2 are increased in patients with advanced NSCLC,which can be used as evaluation indicators of chemotherapy efficacy and prognosis.

关 键 词：肺癌 POKEMON 前梯度蛋白2 临床意义 预后 

分 类 号：R734.2[医药卫生—肿瘤]