MnSOD基因Val16Ala多态性与前列腺癌骨转移患者易感性的关系  

The Relationship Between MnSOD Gene Val16Ala Polymorphism and the Susceptibility of Prostate Cancer Patients with Bone Metastasis

作　　者：孙俊红[1] 张方方 张丽媛[1] 李雷花[1] SUN Junhong;ZHANG Fangfang;ZHANG Liyuan(Puyang People's Hospital,Puyang,457000)

机构地区：[1]河南省濮阳市人民医院,457000

出　　处：《实用癌症杂志》2024年第1期70-73,共4页The Practical Journal of Cancer

摘　　要：目的探讨MnSOD基因Val16Ala多态性与前列腺癌骨转移患者易感性的关系。方法选择94例前列腺癌患者为研究对象。根据患者是否发生骨转移进行分组,将前列腺癌发生骨转移的患者作为骨转移组,将前列腺癌未发生骨转移的患者作为前列腺癌组。统计分析骨转移组与前列腺癌组患者临床资料(年龄、病程、TNM分期、体质量指数等)、两组MnSOD基因Val16Ala遗传平衡检验、MnSOD基因Val16Ala多态性分布以及携带不同基因型前列腺癌骨转移患者临床特征。结果骨转移组40例,前列腺癌54例。两组年龄、病程、TNM分期、体质量指数等临床资料比较,差异无统计学意义(P>0.05)。骨转移组和前列腺癌组MnSOD基因Val/Val、Val/Ala和Ala/Ala基因型实际频数和理论频数分布比较,差异无统计学意义(P>0.05)。骨转移组MnSOD基因Ala/Ala基因型、Ala等位基因频率高于前列腺癌组,Val/Val基因型频率、Val等位基因频率低于前列腺癌组(P<0.05)。MnSOD基因Val16Ala基因型与前列腺癌骨转移患者PSA、年龄以及Gleason评分无关(P>0.05);TNM分期为Ⅲ~Ⅳ期患者Ala/Ala比例75.00%(18/24)显著高于Ⅰ~Ⅱ期患者(P<0.05)。结论MnSOD基因Val16Ala多态性与前列腺癌骨转移患者易感性存在关系,可能存在促进前列腺癌发生骨转移的作用。Objective To investigate the relationship between the polymorphism of MnSOD gene Val16Ala and the susceptibility of prostate cancer patients with bone metastasis.Methods 94 patients with prostate cancer were selected as the study objects.Patients were grouped according to whether or not they had bone metastasis.Patients with prostate cancer with bone metastasis were classified as bone metastasis group and patients without bone metastasis were classified as prostate cancer group.Clinical data(age,course of disease,TNM stage,body mass index,etc.),genetic balance test of MnSOD gene Val16Ala in the two groups,distribution of MnSOD gene Val16Ala polymorphism,and clinical characteristics of prostate cancer patients with different genotypes of bone metastasis were analyzed.Results There were 40 cases of bone metastasis and 54 cases of prostate cancer.There was no significant difference in age,course of disease,TNM stage and body mass index between the two groups(P>0.05).There was no significant difference in the actual and theoretical frequency distribution of MnSOD gene Val/Val,Val/Ala and Ala/Ala genotypes between bone metastasis group and prostate cancer group(P>0.05).The frequencies of MnSOD gene Ala/Ala genotype and Ala allele in bone metastasis group were higher than those in prostate cancer group,and the frequencies of Val/Val genotype and Val allele were lower than those in prostate cancer group(P<0.05).There was no significant difference between MnSOD gene Val16Ala genotype and PSA,age and Gleason score in prostate cancer patients with bone metastasis(P>0.05).The proportion of Ala/Ala in patients with TNM stageⅢ~Ⅳwas 75.00%(18/24)significantly higher than that in patients with stageⅠ~Ⅱ(P<0.05).Conclusion The polymorphism of MnSOD gene Val16Ala is related to the susceptibility of prostate cancer patients with bone metastasis,and may promote the occurrence of bone metastasis of prostate cancer.

关 键 词：前列腺癌 骨转移 MnSOD基因 Val16Ala多态性 易感性 

分 类 号：R737.25[医药卫生—肿瘤]