抗肿瘤中药口服不良反应及药学服务干预措施分析  

Analysis on Adverse reactions to Oral Traditional Chinese Medication for Cancer and Pharmaceutical interventions

作　　者：肖彦芝 康懿荣 Xiao Yanzhi;Kang Yirong(Department of Pharmacy,the Second Affiliated Hospital of Air Force Military Medical University,Xi'an 710038,Shaanxi Prov-ince,China)

机构地区：[1]空军军医大学第二附属医院药剂科,陕西西安710038

出　　处：《中外医药研究》2023年第28期3-5,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨抗肿瘤中药口服不良反应及药学服务干预措施。方法:选取2022年5月—2023年5月于空军军医大学第二附属医院口服抗肿瘤中药出现不良反应的患者48例为观察对象,分析患者年龄分布和该病类型,分析导致不良反应的药物品种分析不良反应的累及系统及发生原因,探讨药学服务干预措施。结果:48例患者中,年龄≥60岁的患者占比最高,年龄<40岁患者占比最低;疾病种类占比最高为肝癌,其次分别为胃癌和食管癌、乳腺癌、肺癌和其他、鼻咽癌;多药合用是引发不良反应的主要原因,其次为白花蛇舌草和蜈蚣;不良反应主要累及消化系统,其次分别为皮肤和附件、神经系统、血管系统、泌尿系统、其他;个体差异引发不良反应最多,其次分别为疗程过长、药物因素、剂量过大等。结论:针对需要口服抗肿瘤中药的患者,需要提高对中药不良反应的重视度,加强药学服务干预,做好用药质量管理、药物宣传等工作,提高用药的合理性。Objective:to explore the adverse reactions of traditional Chinese medicines for cancers and its pharmaceutical inter⁃ventions.Methods:48 patients who suffered from adverse reactions to traditional Chinese medication for cancer in the Second Af⁃filiated Hospital of Air Force Military Medical University from May 2022 to May 2023 were selected for the study.The age of pa⁃tients,drug varieties and their adverse reactions and possible causes were analyzed to explore the interventions of pharmacy servic⁃es.Results:Among the 48 patients,the patients aged≥60 years had greatest percentage while patients aged<40 years the lowest percentage;the highest percentage of cancer disease was liver cancer,followed by stomach and esophageal cancer,breast cancer,lung cancer and nasopharyngeal cancer,respectively;the multi-herbal combination was the main reason for the adverse reactions,followed by the combination of Bai Hua She Cao(Bupleurum officinale)and Wu gong(centipede);the adverse reactions mainly in⁃volved the digestive system,followed by the skin and adnexa,nervous system,vascular system,urinary system,and others;patient individual constitutional differences triggered the most adverse reactions.And a long a course of treatment,over dosage and medic⁃inal factor contribute also to the occurrence.Conclusion:For patients who take traditional Chinese medicine orally for cancer,it is necessary to raise the importance of its adverse reactions,strengthen the intervention of pharmacy service,the quality management of medication need to be done.

关 键 词：抗肿瘤中药 口服 不良反应 药学服务干预 个体差异 

分 类 号：R73[医药卫生—肿瘤]