中药熏洗联合蛋黄油治疗肺癌靶向药物相关性皮疹临床效果及对血液指标、复发率影响  

Clinical Effect of Fumigation with Traditional Chinese Medicine Combined with Egg Butter in the Treatment of Rashes Associated with Targeted Drugs for Lung Cancer and Its Impact on Blood Indexes and Recurrence Rate

作　　者：黄爱云 梁菁 陈星宇 李枋霏 王维 HUANG Aiyun;LIANG Jing;CHEN Xingyu;LI Fangfei;WANG Wei(TCM Tumor Treatment Center,Cancer Hospital Affiliated to Chongqing University,Chongqing 400030,China)

机构地区：[1]重庆大学附属肿瘤医院中医肿瘤治疗中心,重庆400030

出　　处：《临床误诊误治》2023年第7期82-85,96,共5页Clinical Misdiagnosis & Mistherapy

基　　金：重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0501)。

摘　　要：目的 探讨中药熏洗联合蛋黄油治疗肺癌靶向药物相关性皮疹的临床效果及对血液指标、复发率的影响。方法 选取2019年3月—2021年3月收治的肺癌口服靶向药物并出现相关性皮疹80例,根据治疗方法不同将其分为观察组和对照组2组各40例。观察组给予中药熏洗联合蛋黄油治疗,对照组给予糠酸莫米松乳膏治疗。观察比较2组治疗后皮疹分级改善情况、临床效果,治疗前后焦虑和抑郁量表评分、生活质量(QOL)评分、血液安全性指标,以及停药4周后皮疹复发情况。结果 治疗前后2组皮疹分级和治疗后2组临床效果经等级资料秩和检验显示差异均具有统计学意义(P<0.05)。治疗后,2组汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分均低于治疗前,QOL评分高于治疗前;观察组HAMA和HAMD评分低于对照组,QOL评分高于对照组(P<0.01)。治疗前后,2组血清丙氨酸转氨酶、天冬氨酸转氨酶和肌酐比较差异无统计学意义(P>0.05)。停药4周后,观察组皮疹复发率40.0%(16/40)低于对照组72.5%(29/40)(P<0.05)。结论 中药熏洗联合蛋黄油治疗肺癌靶向药物相关性皮疹效果确切,有助于防止皮疹复发。Objective To investigate the clinical effect of fumigation with traditional Chinese medicine combined with egg butter in the treatment of rashes associated with targeted drugs for lung cancer and its impact on blood indexes and recurrence rate.Methods A total of 80 lung cancer patients who were treated with oral targeted drugs and developed associated rashes from March 2019 to March 2021 were selected,and divided into observation group(n=40) and control group(n=40) according to different treatment methods.The observation group was treated with traditional Chinese medicine fumigation combined with Egg butter,and the control group was treated with Mometasone Furoate cream.The improvement of rash grade,clinical effect,anxiety and depression scale score,quality of life(QOL) score,blood safety index before and after treatment,and rash recurrence at 4 weeks after drug withdrawal were observed and compared between the two groups.Results There were significant differences between the two groups with respect to rash grade before and after treatment and the clinical effect of the two groups after treatment by the rank and rank test(P<0.05).After treatment,the scores of Hamilton Anxiety Scale(HAMA) and Hamilton Depression Scale(HAMD) in the two groups were lower than those before treatment,and the QOL scores were higher than those before treatment.The HAMA and HAMD scores of the observation group were lower than those of the control group,while the QOL scores were higher than those of the control group(P<0.01).Before and after treatment,there was no significant difference in serum alanine aminotransferase,aspartate aminotransferase and creatinine between the two groups(P>0.05).At 4 weeks after drug withdrawal,the recurrence rate of skin rash in the observation group was lower than that in the control group [40.0%(16/40) vs.72.5%(29/40)](P<0.05).Conclusion Traditional Chinese medicine fumigation combined with egg butter is effective in the treatment of rashes associated with targeted drugs for lung cancer,which is helpful to

关 键 词：中药熏洗 蛋黄油 肺肿瘤 靶向药物 疹 汉密尔顿焦虑量表 汉密尔顿抑郁量表 生活质量评分 

分 类 号：R734.2[医药卫生—肿瘤] R751[医药卫生—临床医学]