克罗恩病相关肠纤维化生物标志物的研究进展  

Research progress on biomarkers of Crohn disease-related intestinal fibrosis

作　　者：刘子豪 刘明珠 彭娅[1] 徐晓平[1] 吴明浩[1] Liu Zihao;Liu Mingzhu;Peng Ya;Xu Xiaoping;Wu Minghao(Department of Gastroenterology,Hunan Provincial People′s Hospital(the First Affiliated Hospital of Hunan Normal University),Changsha 410000,China)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)消化内科,长沙410000

出　　处：《中国医师杂志》2023年第12期1905-1909,共5页Journal of Chinese Physician

基　　金：国家自然科学基金(81900466);湖南省自然科学基金(2020JJ5307)。

摘　　要：克罗恩病易出现肠纤维化、狭窄甚至肠梗阻的并发症,治疗手段有限,效果不佳。其发病机制涉及遗传、免疫、环境、肠道微生态等方面。探求克罗恩病肠纤维化狭窄的早期预测因子,帮助疾病早期预测、病情评估、治疗评价、复发监测有重要意义。本文围绕目前克罗恩病相关肠纤维化的生物标志物进行系列综述。Crohn disease is prone to complications such as intestinal fibrosis,stenosis,and even intestinal obstruction,with limited treatment options and unsatisfactory results.Its pathogenesis involves genetic,immune,environmental,and gut microbiota aspects.Exploring early predictive factors for intestinal fibrosis stenosis in Crohn disease plays an important role in early disease prediction,disease assessment,treatment evaluation,and recurrence monitoring.This article provides a series of reviews on the current biomarkers of Crohn disease-related intestinal fibrosis.

关 键 词：克罗恩病 肠纤维化 生物学标记 

分 类 号：R574[医药卫生—消化系统]