基于磁共振3D-T_(1)WI评估肺癌化疗患者脑形态学改变的研究  

Evaluation of Brain Morphologic Changes in Lung Cancer Patients after Chemotherapy Based on MRI 3D-T_(1)WI

作　　者：陈文倩 韩小伟 荣萍 李茗[1] 张冰[1] 吕品 CHEN Wen-qian;HAN Xiao-wei;RONG Ping;Li Ming;ZHANG Bing;LV Pin(Department of Radiology,Nanjing Drum Tower hospital,the Affiliated Hospital of Nanjing University Medicine School,Nanjing 210008,Jiangsu Province,China)

机构地区：[1]南京大学医学院附属鼓楼医院医学影像科,江苏南京210008

出　　处：《中国CT和MRI杂志》2024年第1期11-14,共4页Chinese Journal of CT and MRI

基　　金：国家自然科学基金项目(82171908,81720108022)。

摘　　要：目的基于MRI 3D-T_(1)WI探讨化疗对肺癌患者脑形态学改变的影响。方法回顾性分析34名肺癌化疗患者、49名肺癌未化疗患者和40名年龄、性别、受教育年限匹配的健康对照组的头颅3D-T_(1)WI图像,其中化疗患者中14人有化疗前影像数据。对全脑进行标准化处理并分割为48个脑区,通过单因素ANOVA检验统计三组人群(肺癌化疗,肺癌未化疗,健康对照)的脑区体积差异,在每两组之间进行独立样本t检验,并对14名化疗前后的数据进行配对样本t检验。结果ANOVA分析结果表明三组人群的脑体积差异没有统计学差异(P>0.05),但两组之间存在统计学差异脑区;14名肺癌患者化疗前后有10个脑区体积具有统计学差异(P<0.05),分别是壳核(右侧),丘脑(总体,右侧),苍白球(总体,右侧),杏仁核(总体,右侧,左侧),伏隔核(总体,右侧),化疗患者小脑灰质(总体,左侧)和海马(总体、左侧)与肿瘤尺寸之间存在显著负相关。结论肺癌及化疗均引起患者脑形态学特别是体积发生改变。Objective To evaluate the brain morphologic changes in lung cancer patients after chemotherapy based on MRI 3D-T_(1)WI.Methods The 3D-T_(1)WI Image of 34 lung cancer patients with chemotherapy,49 lung cancer patients without chemotherapy,and 40 healthy controls with matched age,sex,and years of education were retrospectively analyzed,including 14 patients had imaging both before and after chemotherapy.The brain was standardized and divided into 48 brain regions.The differences in brain region volume of the three groups(lung cancer chemotherapy,lung cancer without chemotherapy,healthy control)were statistically analyzed by univariate ANOVA test.Independent sample T test was performed between each two groups,and paired sample T test was performed for 14 patients before and after chemotherapy.Results ANOVA analysis showed that there was no significant difference in brain volume between the three groups(P>0.05),but there were significant differences in brain regions between the two groups.For 14 patients,there were statistically significant differences in 10 brain regions(P<0.05),including putamen(right),thalamus(total,right),globus pallidus(total,right),amygdala(total,right,left),accumbens(total,right).There was a significant negative correlation between tumor size and cerebellar gray matter(total,right)and hippocampus(total,left).Conclusion Both Lung cancer and chemotherapy caused changes in brain morphology,especially the brain volume.

关 键 词：肺癌 化疗 头颅磁共振 脑形态学 肿瘤尺寸 

分 类 号：R734.2[医药卫生—肿瘤]