视网膜小胶质细胞在致盲性眼病中的作用  

The role of retinal microglia in blinding eye diseases

作　　者：李宛谦 侯胜平 Li Wanqian;Hou Shengping(Department of Ophthalmology,The First Affiliated Hospital of Chongqing Medical University,Chongqing Key Laboratory of Ophthalmology,Chongqing 400016,China;Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology&Visual Sciences,Beijing 100730,China)

机构地区：[1]重庆医科大学附属第一医院眼科眼科学重庆市重点实验室,重庆400016 [2]首都医科大学附属北京同仁医院、北京同仁眼科中心、北京市眼科研究所眼科学与视觉科学北京市重点实验室,北京100730

出　　处：《国际眼科纵览》2023年第6期498-503,共6页International Review of Ophthalmology

基　　金：国家自然科学基金(82070951,82271078)。

摘　　要：视网膜小胶质细胞是视网膜的常驻免疫细胞,对维持眼内微环境的动态平衡起着关键作用。小胶质细胞的功能多样,可塑性强,受外界刺激时激活的小胶质细胞可以发挥保护组织和加剧损伤的双重作用。视网膜小胶质细胞参与了葡萄膜炎、年龄相关性黄斑变性、糖尿病视网膜病变等多种致盲性眼病的发生发展。Microglia are retinal resident immune cells,which are particularly critical for maintaining the dynamic balance of the retinal microenvironment.Microglia have diverse functions,strong plasticity,and activated microglia can play a dual role in protecting tissue and exacerbating damage in response to external stimuli.There is growing evidence that retinal microglia are involved in the development of a variety of blinding eye diseases,such as uveitis,age-related macular degeneration(AMD)and diabetic retinopathy(DR).

关 键 词：视网膜 小胶质细胞 免疫 

分 类 号：R77[医药卫生—眼科]