晶状体囊膜移植的应用进展  

Advances in the application of lens capsule grafting

作　　者：郭昭琼 俞方良[3] Guo Zhaoqiong;Yu Fangliang(The Third Clinical Medical College of Nanchang University,Nanchang 330008,China;Department of Ophthalmology,Nanchang Fisrt Hospital,Nachang 330008,China;Eye Affiliated Hospital to Nanchang University,Nanchang 330008,China)

机构地区：[1]南昌大学第三临床医学院,南昌330008 [2]南昌市第一医院眼科,南昌330008 [3]南昌大学附属眼科医院,南昌330008

出　　处：《国际眼科纵览》2023年第6期530-535,共6页International Review of Ophthalmology

基　　金：2023年度江西省卫生健康委科技计划项目(SKJP220229728)。

摘　　要：晶状体囊膜可作为一种良好的细胞生长的支架,有弹性、延展性、透明性,在白内障手术中可获得,是一种来源简单且广泛的自体材料,可作为移植物用于抗青光眼、治疗难治性黄斑裂孔及角膜溃疡的手术中。在小梁网切除联合白内障摘除、人工晶状体植入术中,将自体晶状体前囊膜衬垫在巩膜瓣下,既能很好地起到机械阻隔作用,又能抑制新生血管发生、防止瘢痕性滤过泡形成;晶状体囊瓣移植在黄斑裂孔手术修复中促进Müller细胞的增生和迁移,从而促进黄斑裂孔愈合;在体外实验中,晶状体囊膜可促进角膜上皮细胞生长黏附,替代后弹力层,维持角膜的透明,可能为治疗角膜溃疡提供一种新的方法。As a scraffold for good cell growth,the lens capsule is elastic,malleable,transparent,and available in cataract surgery,and is a simple and widely derived autologous material,which can be used as a graft in anti-glaucoma,treatment of refractory macular hole and corneal ulcer surgery.In trabeculectomy combined with cataract extraction and intraocular lens implantation,the autologous anterior capsule liner is padded under the scleral flap,which can not only play a good role in mechanical barrier,but also inhibit the occurrence of neovascularization and prevent the formation of cicatricial filter vesicles.Lens capsular flap transplantation promotes the proliferation and migration of Müller cells during macular hole surgical repair,thereby promoting macular hole healing;In vitro experiments,the lens capsule promotes corneal epithelial cell growth,adhesion and replacement of the Descemet's layer,maintaining corneal transparency.It may provide a new method for treating corneal ulcers.

关 键 词：晶状体囊膜 移植 青光眼 难治性黄斑裂孔 角膜溃疡 

分 类 号：R779.6[医药卫生—眼科]