未折叠蛋白反应与生理性衰老及眼部神经血管退行性疾病的关系  

The unfolded protein response in physiological aging and neurovascular degenerative diseases

作　　者：金一帆 邹佳钰 吴彬榕 张绍丹 Jin Yifan;Zou Jiayu;Wu Binrong;Zhang Shaodan(National Clinical Research Center for Ocular Disease,Eye Hospital,Wenzhou Medical University,Wenzhou Zhejiang 325027,China)

机构地区：[1]温州医科大学附属眼视光医院、国家眼耳鼻喉疾病(眼部疾病)临床医学研究中心,浙江温州325027

出　　处：《国际眼科纵览》2023年第6期570-576,共7页International Review of Ophthalmology

基　　金：国家自然科学基金面上项目(82070958);浙江省卫生健康科技计划(2021KY811);温州医科大学附属眼视光医院创新引导课题院内重点项目(YNZD2201903)。

摘　　要：未折叠蛋白反应(unfolded protein response,UPR)是细胞维持蛋白稳态至关重要的途径。是当细胞内外环境受到刺激时,如氧化应激、炎症、钙失衡等会引起细胞内外蛋白质的稳态失衡,从而导致细胞内蛋白质的聚集或异常蛋白的积累,进一步诱发内质网应激,后续发生一系列的反应来试图恢复蛋白质稳态的过程。当适应性UPR不能恢复细胞内蛋白质稳态时,则会进一步引起细胞凋亡。UPR是生理性和病理性衰老,以及神经血管退行性疾病发生发展的重要影响因素。The unfolded protein response(UPR)is a crucial pathway for cells to maintain protein homeostasis.The protein homeostasis of cells will be disrupted,when the internal and external environment of cells is stimulated,such as redox,inflammation or calcium imbalance.Then it will cause protein aggregation or accumulation of abnormal proteins,which further induces endoplasmic reticulum stress,followed by a series of reactions to restore protein homeostasis.If the adaptive UPRs fail to restore protein homeostasis,it will further induce apoptosis.UPR is an important factor affecting physiological and pathological aging,as well as the occurrence and development of neurovascular degenerative diseases.

关 键 词：未折叠蛋白反应 衰老 神经血管退行性疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]