腭裂术后软腭肌肉再生的机制  

Mechanism of soft palate muscle regeneration after cleft palate surgery

作　　者：李桂影 吴镝 Li Guiying;Wu Di(Department of Cleft Lip and Palate,Plastic Surgery Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100144,China)

机构地区：[1]中国医学科学院北京协和医学院整形外科医院唇腭裂整形科,北京100144

出　　处：《中华整形外科杂志》2023年第12期1366-1370,共5页Chinese Journal of Plastic Surgery

基　　金：中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-052);中国医学科学院整形外科医院院所基金(YS202020)。

摘　　要：腭裂是最常见的口腔颌面畸形之一, 可以通过外科手术进行治疗。与其他部位肌肉相比, 软腭肌肉的再生能力较低, 并且软腭肌肉再生过程中伴随的纤维化程度较高, 因此腭裂术后软腭肌肉再生功能的改善常常难以达到最佳的预期效果。此外, 卫星细胞作为肌肉干细胞在软腭肌肉再生过程中也起到重要作用。该文将讨论腭裂术后肌肉再生机制及伴随的纤维化问题, 分析影响软腭肌肉再生的诸多因素, 并总结了相应的改善软腭肌肉再生功能的治疗方法。Cleft palate is one of the most common oral and maxillofacial deformities,which can be treated through surgery.Compared to other skeletal muscles,the soft palate muscles have a lower regenerative capacity,and tend to develop more fibrosis than other skeletal muscles.It is difficult to achieve the best desired improvement in the function of the soft palate muscles after cleft palate surgery.In addition,satellite cells,which are considered as muscle stem cells,also play an important role in the process of soft palate muscle regeneration.This article will discuss the mechanism of the soft palate muscle regeneration after cleft palate surgery and the accompanying fibrosis process.It will also analyze the factors that affect the regeneration of soft palate muscles and summarize the corresponding methods to improve the muscle regeneration function after cleft palate surgery.

关 键 词：腭裂 肌肉再生 卫星细胞 纤维化 组织工程 

分 类 号：R782.22[医药卫生—口腔医学]