VAV家族在膀胱尿路上皮癌中的表达及其与预后的关系  

Expression of VAV family in bladder urothelial carcinoma and its relationship with prognosis

作　　者：黄翔 蔡宏佳 张能 HUANG Xiang;CAI Hongjia;ZHANG Neng(Department of Urologic Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医科大学附属医院泌尿外科,贵州遵义563000

出　　处：《现代医药卫生》2024年第1期10-13,19,共5页Journal of Modern Medicine & Health

基　　金：贵州省遵义市科技支撑计划项目(遵市科合HZ字[2019]73号);遵义医科大学附属医院硕士科研启动基金项目(院字[2017]34号)。

摘　　要：目的研究VAV家族(VAV1、VAV2、VAV3)在膀胱尿路上皮癌中的表达情况,分析VAV1、VAV2、VAV3与膀胱尿路上皮癌患者预后的关系。方法通过TCGA数据库下载膀胱尿路上皮癌及正常膀胱尿路上皮组织的数据,使用R语言提取数据后进行分析,获取VAV1、VAV2、VAV3在膀胱尿路上皮癌及正常膀胱尿路上皮组织中的表达情况,以及根据患者结局绘制生存曲线图。进一步对在膀胱尿路上皮癌组织中进行免疫组织化学验证。结果VAV1在膀胱尿路上皮癌组织及正常膀胱尿路上皮组织中表达比较,差异无统计学意义(P>0.05),VAV2、VAV3在膀胱尿路上皮癌组织中表达高于正常膀胱尿路上皮组织,差异有统计学意义(P<0.05),与膀胱的分化程度无明显相关性(P>0.05)。VAV1、VAV2的表达与患者生存时间无明显相关性(P>0.05),VAV3表达越高,患者生存时间越短(P<0.0001)。结论VAV2、VAV3可能参与膀胱尿路上皮癌的变化进展,VAV3可能与患者不良预后有关。Objective To study the expression of VAV family(VAV1,VAV2,VAV3) in bladder urothelial carcinoma,and to analyze the relationship between VAV1,VAV2,VAV3 and prognosis of the patients with bladder urothelial carcinoma.Methods The data of bladder urothelial carcinoma and normal bladder urothelial tissue were downloaded by the TCGA database,which were extracted by R language for conducting the analysis.The expression situation of each gene in urinary urothelial carcinoma and normal urinary urothelial tissue of bladder was obtained.The survival curve was drawn according to the patient′s outcome and the expression level in bladder urothelial carcinoma was further conducted the immunohistochemistric verification.Results The expression levels of VAV1 had no significant difference between urothelial carcinoma and normal bladder urothelial tissue(P>0.05).The expression levels of VAV2 and VAV3 in the bladder urothelial carcinoma tissue were higher than that in normal bladder urothelial tissues,the difference was statistically significant(P<0.05),and had no significant correlation with the bladder differentiation degree(P>0.05).The expression levels of VAV1 and VAV2 had no significant correlation with the survival time of the patients(P>0.05).The higher the expression of VAV3,the shorter the survival time of the patients(P<0.000 1).Conclusion VAV2 and VAV3 may be involved in the change progression of bladder urothelial carcinoma,and VAV3 may be related to the poor prognosis of the patients.

关 键 词：膀胱尿路上皮癌 VAV1 VAV2 VAV3 预后 

分 类 号：R737.14[医药卫生—肿瘤]