外翻式颈内动脉内膜斑块切除术对老年颈动脉狭窄患者认知功能的影响  

Effect of eversion carotid endarterectomy on cognitive function in elderly patients with carotid artery stenosis

作　　者：刁光亮 李伟 段丽红 苏宏斌 刘炳鑫 郭曙光 尹存平 Diao Guangliang;Li Wei;Duan Lihong;Su Hongbin;Liu Bingxin;Guo Shuguang;Yin Cunping(Department of Vascular Surgery,No.920 Hospital of PLA Joint Logistic Support Force,Kunming 650032,Yunnan Province,China)

机构地区：[1]解放军联勤保障部队第九二〇医院血管外科,昆明650032

出　　处：《中华老年心脑血管病杂志》2023年第10期1056-1059,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：云南省科技计划项目(202201AY070001-289),解放军联勤保障部队第九二〇医院院内科技计划项目(2020YGA04)。

摘　　要：目的探讨外翻式颈内动脉内膜斑块切除术(eCEA)对不同年龄段老年颈动脉狭窄患者认知功能的影响。方法选取2019年5月至2022年5月解放军联勤保障部队第九二〇医院血管外科行eCEA的老年患者56例,根据年龄分为60~69岁组31例,70~80岁组25例。采用简易智能状态检查量表(MMSE)评分对2组患者术前1周内、术后1个月、6个月进行分析。结果60~69岁组术后1个月、6个月MMSE评分较术前明显增高[(24.71±3.67)分vs(23.52±3.70)分,P<0.05;(25.48±3.19)分vs(23.52±3.70)分,P<0.01]。70~80岁组术后6个月MMSE评分较术前、术后1个月明显增高[(25.44±3.42)分vs(23.76±3.81)分,P<0.01;(25.44±3.42)分vs(23.90±3.65)分,P<0.01]。60~69岁组术后1个月-术前MMSE评分改善程度较70~80岁组明显增高,术后6个月-术后1个月MMSE评分改善程度较70~80岁组明显降低,差异有统计学意义(P<0.05)。结论老年颈动脉狭窄患者行eCEA能够明显改善认知功能,且60~69岁的患者在早期即可见明显效果。Objective To explore the effect of eversion carotid endarterectomy(eCEA)on the cog-nitive function in elderly carotid artery stenosis patients with different ages.Methods A total of 56 elderly patients undergoing eCEA in Department of Vascular Surgery of No.920 Hospital of Joint Logistics Support Force from May 2019 to May 2022 were enrolled and divided intoa 60-69 year old group(31 cases)and a 70-80 year old group(25 cases).Minimental state examination(MMSE)Scale was used to analyze the patients within 1 week before surgery and 1 and 6 months after surgery.Results In the 60-69 years old group,their MMSE scores in 1 and 6 months after surgery were significantly higher than those before surgery(24.71±3.67 us 23.52±3.70,P<0.05;25.48±3.19 vs 23.52±3.70,P<0.01).For the 70-80 year old group,the MMSE score in 6 months after surgery was obviously higher than that before surgery and that in 1 month after sur-gery(25.44±3.42 Us 23.76±3.81,P<0.01;25.44±3.42 Us 23.90±3.65,P<0.01).The improve-ment of MMSE score between 1 month after surgery and before surgery was notably more obvi-ous in the 60-69 year old group than the 70-80 year old group,but the improvement between 6 months and 1 month after surgery was statistically declined in the 60-69 year old group than the 70-80 year old group(P<0.05).Conclusion eCEA can significantly improve cognitive function in elderly patients with carotid artery stenosis,and obvious efficacy is observed in the early stage in the 60-69 years old patients.

关 键 词：颈动脉狭窄 认知 斑块切除术 外翻式颈内动脉内膜斑块切除术 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R654.3[医药卫生—临床医学]