血清肿瘤标志物PRO-GRP、NSE、CEA、CYFRA21-1及SCC对肺癌早期诊断的价值  

Value of PRO-GRP,NSE,CEA,CYFRA21-1 and SCC serum tumor markers in the early diagnosis of lung cancer

作　　者：迟静 刘伟 CHI Jing(Department of Laboratory Medicine,Chuzhou City Vocational College,Chuzhou 239000,China)

机构地区：[1]滁州城市职业学院医学院检验系 [2]滁州市名儒医院检验科,安徽滁州239000

出　　处：《牡丹江医学院学报》2023年第6期50-54,共5页Journal of Mudanjiang Medical University

基　　金：安徽省高校自然科学研究重点项目(KJ2021A1413)。

摘　　要：目的评估胃泌素释放肽前体(Pro-gastrin-releasing peptide,PRO-GRP)、神经元特异性烯醇酶(Neuron-specific enolase,NSE)、癌胚抗原(Carcinoembryonic antigen,CEA)、细胞角蛋白-19片段21-1(Cytokeratin-19 fragment 21-1,CYFRA21-1)及鳞状细胞癌抗原(Squamous cell carcinoma antigen,SCC)血清肿瘤标志物在肺癌早期诊断中的价值,并探究它们作为诊断指标的组合效应。方法选择2020年1月至2022年10月期间收治的60例肺癌患者作为阳性组,同时纳入90例良性肺疾病患者作为阴性组。所有患者均接受血清肿瘤标志物检测,检测方法为免疫化学发光法,检测指标包括:PRO-GRP、NSE、CEA、CYFRA21-1及SCC。比较两组患者血清标志物的含量,并分析其阴阳表达情况。利用二元多因素回归分析,将这些标志物作为自变量,是否诊断为肺癌阳性作为因变量,探究其对肺癌诊断的独立危险因素。应用ROC曲线分析评估单独及联合检测这些标志物对肺癌的诊断价值,统计ROC曲线下面积(Area Under the Curve,AUC)、敏感度和特异度。结果阳性组患者的血清PRO-GRP、NSE、CEA、CYFRA21-1、SCC含量均显著高于阴性组(P<0.05)。单因素分析结果显示,这些标志物均为影响肺癌诊断结果的可疑因素(P<0.05)。多因素分析结果表明,它们在肺癌诊断为阳性时均为独立的危险因素(P<0.05)。ROC曲线分析显示,PRO-GRP、NSE、CEA、CYFRA21-1、SCC的单独及联合检测在肺癌诊断中具有统计学意义(P<0.05)。联合预测因子的AUC、敏感度和特异度均高于单独检测指标。结论PRO-GRP、NSE、CEA、CYFRA21-1及SCC血清肿瘤标志物在肺癌早期诊断中具有重要的诊断价值。联合检测这可以提高肺癌早期诊断的准确性,成为有力的肺癌筛查和早期诊断工具。Objective To evaluate the value of serum tumor markers such as PRO-GRP,NSE,CEA,CYFRA21-1 and SCC in the early diagnosis of lung cancer,and to explore their combined effect as diagnostic indicators.Methods 60 patients with lung cancer treated between January 2020 and October 2022 were selected as the positive group,and 90 patients with benign lung diseases were included as the negative group.All patients undergo serum tumor marker testing using the chemiluminescent immunoassay method.The testing markers include PRO-GRP,NSE,CEA,CYFRA21-1,and SCC.The levels of serum markers were compared between the two groups,and the expression were analyzed.Using binary multivariate regression analysis,these markers were used as independent variables,and whether a positive diagnosis of lung cancer was used as a dependent variable to explore their independent risk factors for the diagnosis of lung cancer.ROC curve analysis was used to evaluate the diagnostic value of these markers alone and in combination for lung cancer,and the area under the ROC curve(AUC),sensitivity and specificity were calculated.Results Serum PRO-GRP,NSE,CEA,CYFRA21-1,and SCC contents in the positive group were significantly higher than those in the negative group(P<0.05).The results of univariate analysis showed that these markers were all suspicious factors affecting the diagnosis of lung cancer(P<0.05).The results of multivariate analysis showed that they were all independent risk factors when the diagnosis of lung cancer was positive(P<0.05).ROC curve analysis showed that the individual and combined detection of PRO-GRP,NSE,CEA,CYFRA21-1,and SCC had statistical significance in the diagnosis of lung cancer(P<0.05).The AUC,sensitivity and specificity of the combined predictors were higher than those of the individual detection indicators.Conclusion Serum tumor markers such as PRO-GRP,NSE,CEA,CYFRA21-1 and SCC have important diagnostic value in the early diagnosis of lung cancer.Combined detection of these markers can improve the accuracy of early diagnosis

关 键 词：肺癌 血清肿瘤标志物 早期诊断 PRO-GRP NSE CEA CYFRA21-1 SCC 

分 类 号：R734.2[医药卫生—肿瘤]