颈动脉内中膜厚度与血清缺血修饰白蛋白、β2糖蛋白1抗体水平联合检测对LAA型缺血性脑卒中的诊断价值  

The diagnostic value of combined detection of IMT,IMA and anti-β2GPI in LAA ischemic stroke

作　　者：刘坦 赵星鹏 刘辉 LIU Tan(Laboratory Department,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471900,China)

机构地区：[1]郑州大学附属洛阳中心医院检验科,河南洛阳471009

出　　处：《牡丹江医学院学报》2023年第6期55-58,10,共5页Journal of Mudanjiang Medical University

基　　金：河南省医学科技公关计划联合共建项目(LHGJ20200848)。

摘　　要：目的研究大动脉粥样硬化(large artery-atherosclerosis,LAA)型缺血性脑卒中患者颈动脉内中膜厚度(Carotid intima-media thickness,IMT)、缺血修饰白蛋白(ischemia modified albumin,IMA)和β2糖蛋白1抗体(β2 Glycoprotein 1 antibody,抗-β2GPI)水平与正常人群的差异;比较IMT与IMA、抗-β2GPI之间的相关性进而探究三者联合检测对LAA型缺血性脑卒中的诊断价值。方法收集2020年10月至2021年10月期间在郑州大学附属洛阳中心医院进行就诊的70名LAA型缺血性脑卒中患者作为观察组,并选取同期在我院进行健康体检的50名体检者作为健康对照组,分别采用酶循环法、酶联免疫法检测其血清中IMA和抗-β2GPI水平,采用颈动脉超声检查测定颈总动脉IMT值,比较其差异性、相关性及联合检测价值。结果LAA型缺血性脑卒中组IMT、IMA和抗-β2GPI水平显著高于健康对照组:(1.26±0.10)、(0.99±0.14);(70.53±3.29)、(63.56±4.15);(22.18±20.18)、(10.62±5.62),存在统计学差异。IMT与IMA呈中度正相关(r=0.588,P<0.05),与抗-β2GPI呈低度正相关(r=0.332,P<0.05)。ROC曲线分析显示IMT、IMA与抗-β2GPI三者联合检测有助于提高LAA型缺血性脑卒中的临床诊断效能。结论LAA型缺血性脑卒中患者颈总动脉IMT值及外周血清IMA、抗-β2GPI水平较正常人群显著增高,三者联合检测对于提高LAA型缺血性脑卒中的临床诊断效能有更大价值。Objective To explore the difference of carotid intima-media thickness(IMT),ischemic modified albumin(IMA)and anti-beta2 glycoprotein I antibody(anti-β2GPI)level between patients with large artery-atherosclerosis(LAA)ischemic stroke and normal population,compare the correlation among carotid intima-media thickness(IMT),ischemia modified albumin(IMA)andβ2 glycoprotein 1 antibody(anti-β2GPI),additionally,explore the diagnostic value of combined detection of the three in LAA ischemic stroke.Methods 70 patients with LAA ischemic stroke who were treated in Luoyang Central Hospital affiliated to Zhengzhou University from October 2020 to October 2021 were collected as the observation group,and 50 people who have health examination in the same period were selected as the health control group.The level of IMA and anti-β2GPI in serum were detected by enzyme circulation method and enzyme-linked immunosorbent assay,and the IMT thickness of common carotid artery were measured by carotid ultrasound.The differences,correlation and combined detection value were also compared.Results The levels of IMT,IMA and anti-β2GPI were significantly higher than that of healthy control group:(1.26±0.10),(0.99±0.14);(70.53±3.29),(63.56±4.15);(22.18±20.18),(10.62±5.62),And there were statistical differences between the two groups.IMT and IMA show moderate positive correlation(r=0.588,p<0.05),IMT and anti-β2GPI show low positive correlation(r=0.332,p<0.05).ROC curve analysis shows that the combined detection of IMT,IMA and anti-β2GPI is helpful to improve the clinical diagnostic efficacy of LAA ischemic stroke.Conclusion The IMT thickness of common carotid artery,the levels of IMA and anti-β2GPI in peripheral serum were significantly higher than that of normal people,and the combined detection of the three has greater value in improving the clinical diagnostic efficacy of LAA ischemic stroke.

关 键 词：颈动脉内中膜厚度 缺血修饰白蛋白 β2糖蛋白1抗体 缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]