EBV-DNA、AGR、IL-6与老年鼻咽癌同步放化疗口腔感染的关系  

Relationship between EBV-DNA,AGR,IL-6 and oral infection in senile nasopharyngeal carcinoma with concurrent chemoradiotherapy

作　　者：尉迟芸耸 齐登高 张博 YUCHI-Yun-song(Radiotherapy Department of Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院放疗科,河南南阳473000

出　　处：《牡丹江医学院学报》2023年第6期92-95,54,共5页Journal of Mudanjiang Medical University

摘　　要：目的探讨EB病毒DNA(EBV-DNA)、白蛋白/球蛋白比值(AGR)、白细胞介素-6(IL-6)与老年鼻咽癌同步放化疗口腔感染的关系。方法选取2020年2月至2023年2月于我院进行同步放化疗的164例老年鼻咽癌患者,根据是否发生口腔感染将患者分为感染组(31例)和未感染组(133例)。比较两组一般临床资料,比较两组治疗前EBV DNA、AGR、IL-6水平,Logistic回归分析老年鼻咽癌同步放化疗患者发生口腔感染的危险因素,分析治疗前EBV DNA、AGR、IL-6水平联合检测对老年鼻咽癌同步放化疗患者发生口腔感染的预测价值。结果两组糖尿病、吸烟、使用抗生素、使用口腔保护剂情况比较,差异有统计学意义(P<0.05);与治疗前未感染组相比,治疗前感染组EBV-DNA、IL-6水平较高,AGR较低,差异具有统计学意义(P<0.05);糖尿病、吸烟、治疗前EBV-DNA、IL-6水平为同步放化疗老年鼻咽癌患者发生口腔感染的危险因素,使用抗生素、使用口腔保护剂、治疗前AGR水平保护因素(P<0.05);治疗前EBV-DNA、AGR、IL-6水平联合预测老年鼻咽癌同步放化疗患者发生口腔感染的曲线下面积(AUC)大于各单独指标(P<0.05)。结论糖尿病、吸烟、使用抗生素、使用口腔保护剂情况、EBV-DNA、AGR、IL-6均为老年鼻咽癌同步放化疗患者发生口腔感染的影响因素,临床应强化对上述因素的控制,严密监测口腔变化,减少口腔感染发生。Objective To investigate the relationship between EBV-DNA,albumin/globulin ratio(AGR),interleukin-6(IL-6),and oral infection in elderly patients with nasopharyngeal carcinoma.Methods 164 elderly patients with nasopharyngeal carcinoma who received concurrent chemoradiotherapy in our hospital from February 2020 to February 2023 were selected and divided into the infected group(31 cases)and the uninfected group(133 cases)according to whether oral infection occurred.General clinical data of the two groups were compared,EBV DNA,AGR and,IL-6 levels were compared before treatment,and the risk factors of oral infection in elderly patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy were analyzed by Logistic regression.To analyze the predictive value of EBV DNA,AGR and,IL-6 levels in oral infection in elderly patients with nasopharyngeal carcinoma before treatment.Results There were statistically significant differences in diabetes,smoking,antibiotic use and,oral protective agent use between the two groups(P<0.05).Compared with the uninfected group,the levels of EBV-DNA and IL-6 in the infected group before treatment were higher and the AGR was lower,the difference was statistically significant(P<0.05).Diabetes,smoking,EBV-DNA and,IL-6 levels before treatment were risk factors for oral infection in elderly patients with nasopharyngeal carcinoma,and the use of antibiotics,oral protective agents and AGR level before treatment were protective factors(P<0.05).Before treatment,the AUC of EBV-DNA,AGR and,IL-6 combined predicted oral infection in elderly patients with concurrent chemoradiotherapy of nasopharyngeal carcinoma was greater than each index(P<0.05).Conclusion Diabetes mellitus,smoking,use of antibiotics,use of oral protective agents,EBV-DNA,AGR and IL-6 are all influential factors for oral infection in elderly patients with nasopharyngeal carcinoma.Clinical control of these factors should be strengthened,and oral changes should be closely monitored to reduce the incidence of oral infection.

关 键 词：鼻咽癌 同步放化疗 口腔感染 EBV-DNA AGR IL-6 

分 类 号：R739.63[医药卫生—肿瘤]