CalliSpheres药物洗脱微球和空白微球经动脉化疗栓塞术治疗中晚期非小细胞肺癌的比较  

Clinical efficacy of CalliSpheres drug⁃loaded microspheres versus blank microspheres in the treatment of advanced non⁃small cell lung cancer by transarterial chemoembolization

作　　者：程瑞文 郝若冰 李平[2] 张堃[2] 邓梨平[1] 曹亚衡 粟麟 沈宏荣[2] CHENG Ruiwen;HAO Ruobing;LI Ping;ZHANG Kun;DENG Liping;CAO Yaheng;SU Lin;SHEN Hongrong(Department of Vascular and Tumor Intervention,the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410021,China;不详)

机构地区：[1]湖南中医药大学第一附属医院血管肿瘤介入科,长沙410021 [2]湖南中医药大学第一附属医院放射科,长沙410021

出　　处：《实用医学杂志》2024年第1期32-37,共6页The Journal of Practical Medicine

基　　金：湖南省卫生健康委科研计划项目(编号:D202309046436);湖南中医药大学教学改革研究项目(编号:2019-JG041)。

摘　　要：目的回顾性分析并比较CalliSpheres药物洗脱微球和空白微球经支气管动脉化疗栓塞术治疗中晚期非小细胞肺癌的临床疗效。方法收集50例经放、化疗、靶向及免疫治疗后无效或复发的中晚期非小细胞肺癌患者,进行超选择性支气管动脉化疗栓塞治疗。通过回顾性分析,比较CalliSpheres药物洗脱微球和空白微球两组间肿瘤治疗有效率和生存期的差异。结果术后药物洗脱微球组PR、ORR、DCR均高于空白微球组,其中术后1个月两组间DCR差异有统计学意义(χ^(2)=4.08,P=0.04)。术后药物洗脱微球组PD低于空白微球组;术后药物洗脱微球组的CEA、CYF、SCC均低于空白微球组,两组术后CEA、CYF、SCC均低于术前,其中两组间术后1个月CEA、CYF差异有统计学意义(P<0.05);药物洗脱微球组PFS、OS均高于空白微球组。结论CalliSpheres药物洗脱微球相较于空白微球经动脉化疗栓塞术可更有效地提高肿瘤治疗有效率及延长生存时间,为其治疗中晚期非小细胞肺癌提供可靠的临床实践依据。Objective To analyze and compare the clinical efficacy of CalliSpheres drug-eluting micro⁃spheres and blank microspheres in the treatment of advanced non-small cell lung cancer by bronchial arterial chemoembolization.Methods Fifty patients with advanced non-small cell lung cancer who had failed or relapsed after radiotherapy,chemotherapy,targeting and immunotherapy were collected and treated with super-selective bronchial artery chemoembolization.A retrospective analysis was conducted to compare the tumor response rate and survival between CalliSpheres drug-eluting and blank microspheres.Results The PR,ORR and DCR in the drug-eluted microsphere group were higher than those in the blank microsphere group,and there was a statistical difference in DCR between the two groups 1 month after surgery(χ^(2)=4.08,P=0.04).PD in the drug-eluted microsphere group was lower than that in the blank microsphere group.The CEA,CYF and SCC in the drug-eluted microsphere group after surgery were lower than those in the blank microsphere group,and the CEA,CYF and SCC in the two groups after surgery were lower than those before surgery,and there were statistical differences in CEA and CYF 1 month after surgery between the two groups.The PFS and OS in drug-eluted microsphere group were higher than those in blank microsphere group.Conclusion CalliSpheres drug-eluting microspheres could improve the effective rate of tumor treatment and prolong the survival time more effectively than the blank micro⁃spheres via arterial chemoembolization,providing reliable clinical practice basis for the treatment of advanced non-small cell lung cancer.

关 键 词：非小细胞肺癌 药物洗脱微球 动脉化疗栓塞术 

分 类 号：R734.2[医药卫生—肿瘤]