鼠神经生长因子联合丙种球蛋白治疗慢性格林巴利综合征临床疗效观察  

Observation on the clinical efficacy of murine nerve growth factor combined with gamma globulin in the treatment of chronic Guillain-Barrésyndrome

作　　者：李雪[1] 王梦涵[1] 张艳[1] 张晶晶[1] LI Xue;WANG Meng-han;ZHANG Yan;ZHANG Jing-jing(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院,河南郑州450000

出　　处：《实用医院临床杂志》2024年第1期155-158,共4页Practical Journal of Clinical Medicine

基　　金：河南省自然科学基金资助项目(编号:19231004250015)。

摘　　要：目的探讨鼠神经生长因子(mNGF)联合丙种球蛋白(IVIG)治疗格林巴利综合征(GBS)的临床疗效及对炎性因子及肌力评分的影响。方法我院收治的73例GBS患者,按治疗方法分为观察组(mNGF联合IVIG治疗)40例和对照组(IVIG治疗)33例。对比两组临床疗效、炎性因子、肌力评分及肢体功能Hughes量表评分,并记录治疗期间不良反应发生率。结果观察组治疗总有效率显著高于对照组(P<0.05);治疗后观察组血清IL-4水平高于对照组,IL-21、IL-23水平低于对照组(P<0.05);治疗后观察组上、下肢肌力评分高于对照组,肢体功能Hughes评分低于对照组(P<0.05)。结论mNGF联合IVIG对慢性GBS的临床效果优于单纯使用IVIG治疗,二者联合治疗可有效抑制相关促炎因子的表达,明显改善患者肌力和肢体功能。Objective To investigate the clinical efficacy of murine Nerve Growth Factor(mNGF)combined with gamma globulin(IVIG)in the treatment of Guillain-Barre syndrome(GBS)and their effects on inflammatory factors and muscle strength scores.Methods Seventy-three GBS patients admitted to our hospital from March 2017 to May 2022 were selected.The patients were divided into an observation group(mNGF combined with IVIG treatment,n=40)and a control group(IVIG treatment,n=33)according to treatment methods.The clinical efficacy,inflammatory factors,muscle strength scores and limb function(Hughes scale scores)were compared between the two groups.The incidence of adverse reactions during treatment was recorded.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the serum levels of interleukin 4(IL-4)in the observation group were higher than those in the control group,while the levels of IL-21 and IL-23 in the observation group were lower than those in the control group(P<0.05).After treatment,the muscle strength scores of upper and lower limbs in the observation group were higher than those in the control group(P<0.05).After treatment,the Hughes score of limb function in the observation group was lower than that in the control group(P<0.05).Conclusions The clinical effect of mNGF combined with IVIG in the treatment of chronic GBS is better than that of IVIG alone.The combination of the two can effectively inhibit the expression of related pro-inflammatory factors,and significantly improve the muscle strength and limb function of the patients.

关 键 词：鼠神经生长因子 丙种球蛋白 慢性格林巴利综合征 炎性因子 肌力评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]