绝经前乳腺癌患者的风险因素及其与分子亚型的关系分析  

Risk factors in premenopausal breast cancer patients and their correlation with molecular subtypes

作　　者：牛露伟 NIU Lu-wei(Department of Thyroid and Breast Surgery,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,China)

机构地区：[1]徐州医科大学附属医院甲状腺乳腺外科,221000

出　　处：《中国实用医药》2023年第24期35-40,共6页China Practical Medicine

摘　　要：目的分析绝经前乳腺癌患者的风险因素及其分子亚型的关系。方法240例行乳腺检查或治疗者,将其中120例绝经前乳腺癌患者作为病例组,另将120例乳腺良性疾病或行乳腺健康检查的绝经前人群作为对照组。比较两组的基本资料,分析乳腺癌分子亚型患病率,采用单因素及多因素Logistic回归分析绝经前乳腺癌及其分子亚型的危险因素。结果两组性别、年龄、身高、文化程度及职业比较,差异无统计学意义(P>0.05)。病例组避孕药物服用史、超重/肥胖史和乳腺良性疾病史占比分别为80.0%、47.5%、15.8%,均高于对照组的47.5%、20.8%、5.8%,差异有统计学意义(P<0.05);两组健身运动、生育史、月经周期、月经量、饮酒、吸烟、乳腺癌家族史、放射性物质接触史比较,差异无统计学意义(P>0.05)。多因素Logistic回归分析显示,避孕药物服用史、超重或肥胖史和乳腺良性疾病为绝经前乳腺癌的独立危险因素(P<0.05)。根据乳腺癌患者术后免疫组化结果,乳腺癌分子亚型最常见的分子亚型为乳腺癌管腔上皮A型(Luminal A),占49.2%,预后较差的三阴性占20.8%。Luminal A、乳腺癌管腔上皮B型(Luminal B)、人表皮生长因子受体-2(HER-2)阳性型、三阴性患者超重/肥胖史情况比较差异具有统计学意义(P<0.05);Luminal A、Luminal B、HER-2阳性型、三阴性患者健身运动、生育史、避孕药物服用史、月经周期、月经量、饮酒、吸烟、乳腺良性疾病史、乳腺癌家族史、放射性物质接触史比较差异无统计学意义(P>0.05)。结论避孕药物服用史、超重或肥胖史和乳腺良性疾病为绝经前乳腺癌的危险因素,并根据分子亚型进行了分层分析。针对绝经前乳腺癌,适当选择避孕药物,控制体重,定期进行乳腺的相关检查等干预措施可能会降低绝经前乳腺癌的发病率。Objective To analyze the risk factors in premenopausal breast cancer patients and their correlation with molecular subtypes.Methods Among 240 subjects undergoing breast screening and treatment,120 premenopausal breast cancer patients were used as case group,and another 120 premenopausal patients with benign breast disease or breast examination were used as control group.The basic data of the two groups was compared,and the prevalence rate of molecular subtypes of breast cancer in the two groups were analyzed.Univariate and multivariate Logistic regression were used to analyze the risk factors of premenopausal breast cancer and its molecular subtypes.Results There was no statistically significant difference in gender,age,height,education level and occupation between the two groups(P>0.05).The prevalence of contraceptive use,overweight/obesity and benign breast disease in the case group were 80.0%,47.5%and 15.8%,which were higher than those of 47.5%,20.8%and 5.8%in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference between the two groups in terms of fitness exercise,reproductive history,menstrual cycle,menstrual volume,drinking,smoking,family history of breast cancer and exposure to radioactive substances(P>0.05).Multivariate Logistic regression analysis showed that history of contraceptive use,overweight or obesity and benign breast disease were independent risk factors for premenopausal breast cancer(P<0.05).According to the postoperative immunohistochemical results of breast cancer patients,the most common molecular subtype of breast cancer was Luminal A,accounting for 49.2%,and triple-negative patients had poor prognosis,accounted for 20.8%.The overweight/obesity history of Luminal A,Luminal B,human epidermal growth factor receptor-2(HER-2)positive and triple-negative patients with was compared,and the difference was statistically significant(P<0.05).Luminal A,Luminal B,HER-2 positive,and triple-negative patients had no statistically si

关 键 词：绝经前乳腺癌 避孕药物 超重/肥胖 乳腺良性疾病 

分 类 号：R737.9[医药卫生—肿瘤]