文拉法辛与艾司西酞普兰治疗抑郁症的疗效及对患者认知功能的影响  

Efficacy of venlafaxine and escitalopram in the treatment of depression and the effects on cognitive function of patients

作　　者：刘琼 谢小丽[1] 尹翼[1] 邓大禧 LIU Qiong;XIE Xiaoli;Yin Yi;Deng Daxi(Ji'an Third People's Hospital,Ji'an,Jiangxi,343000,China)

机构地区：[1]吉安市第三人民医院,江西吉安343000

出　　处：《当代医学》2023年第32期81-84,共4页Contemporary Medicine

摘　　要：目的探究文拉法辛与艾司西酞普兰治疗抑郁症的疗效及对患者认知功能的影响。方法选取2021年1—12月吉安市第三人民医院收治的70例抑郁症患者作为研究对象,随机分为观察组与对照组,每组35例。观察组行文拉法辛治疗,对照组行艾司西酞普兰治疗,比较两组汉密尔顿焦虑量表(HAMA)、评分汉密尔顿抑郁量表(HAMD)评分、认知功能、快感缺失量表(SHAPS)评分、不良反应发生情况及临床疗效。结果治疗前,两组HAMA、HAMD评分比较差异无统计学意义;治疗后,两组HAMA、HAMD评分均低于治疗前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义。治疗前,两组延迟记忆、注意、即刻记忆评分比较差异无统计学意义;治疗后,两组延迟记忆、注意、即刻记忆评分均高于治疗前,差异有统计学意义(P<0.05),但组间比较差异无统计学意义。治疗前,两组SHAPS评分比较差异无统计学意义;治疗后,两组SHAPS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。两组治疗总有效率比较差异无统计学意义。结论文拉法辛、艾司西酞普兰治疗抑郁症疗效相当,均能改善患者认知功能、抑郁症状,但前者更有助于改善快感缺失,值得临床推广应用。Objective To explore the efficacy of venlafaxine and escitalopram in the treatment of depression and the effects on cognitive function of patients.Methods 70 patients with depression admitted to Ji'an Third People's Hospital from January to December 2021 were selected as research subjects,and they were randomly divided into the observation group and the control group,with 35 cases in each group.The observation group was treated with venlafaxine,while the control group was treated with escitalopram.The Hamilton anxiety scale(HAMA)scores and Hamilton depression scale(HAMD)scores,cognitive function,Snaith-Hamilton pleasure scale(SHAPS)scores,adverse reactions and clinical efficacy were compared between the two groups.Results Before treatment,there were no significant differences in the HAMA and HAMD scores between the two groups;after treatment,the HAMA and HAMD scores of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05),but there was no statistically significant difference between groups.Before treatment,there were no significant differences in delayed memory,attention and immediate memory scores between the two groups;after treatment,the scores of delayed memory,attention and immediate memory of the two groups were higher than those before treatment,and the differences were statistically significant(P<0.05),but there was no statistical significance between groups.Before treatment,there was no significant difference in SHAPS scores between the two groups;after treatment,the SHAPS scores of the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.There was no significant difference in the total effective rate between the two groups.Conclusion Venlafaxine and escitalopram have similar curative effects in the treatment of depression,both of which can improve t

关 键 词：文拉法辛 艾司西酞普兰 抑郁症 认知功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学]