Helicobacter pylori infection in pregnant women:Gastrointestinal symptoms and pregnancy-related disorders  

作　　者：Luana Kauany de SáSantos Jonathan Santos Apolonio Beatriz Rocha Cuzzuol Bruna Teixeira da Costa Vinícius Lima de Souza Gonçalves Ronaldo Teixeira da Silva Júnior Marcel Silva Luz Fabian Fellipe Bueno Lemos Samuel Luca Rocha Pinheiro Fabrício Freire de Melo 

机构地区：[1]Instituto Multidisciplinar em Saúde,Universidade Federal da Bahia,Vitória da Conquista 45029-094,Bahia,Brazil [2]Universidade Estadual do Sudoeste da Bahia,Campus Vitória da Conquista,Vitória da Conquista 45083-900,Bahia,Brazil

出　　处：《World Journal of Clinical Infectious Diseases》2023年第5期49-57,共9页世界临床传染病学杂志

摘　　要：Helicobacter pylori(H.Pylori)is a gram-negative,flagellated and spiral-shaped bacterial pathogen that impacts approximately 46%among pregnant women globally and has been associated with various maternal-fetal complications.Iron deficiency anemia,fetal growth restriction,cardiovascular diseases,and insufficient nutrient absorption can be observed in pregnant women,as well as miscarriages and pregnancy-specific hypertensive disease,such as pre-eclampsia.Thus,the evidence supports the influence of H.pylori infection on fetal implantation/placentation failure,and positive strains of the cytotoxin-associated gene A of H.Pylori were reported as the most prevalent in these conditions.However,current knowledge indicates a relationship between this infection and the occurrence of hyperemesis gravidarum,characterized by frequent nausea and vomiting.Regarding the diagnosis of this bacterial infection,non-invasive approaches such as stool antigen test,urea breath test,and serological tests are more accepted during pregnancy,as they are easy to carry out and cost-effective.Finally,the bacteria eradication therapy should consider the risks and benefits for the pregnant woman and her child,with pharmacological intervention depending on the clinical presentation.

关 键 词：Helicobacter pylori PREGNANCY Hyperemesis gravidarum Iron deficiency anemia PRE-ECLAMPSIA Fetal growth restriction MISCARRIAGE 

分 类 号：R57[医药卫生—消化系统]