Potential therapeutic targets for the prevention of diabetic nephropathy:Glycyrrhetinic acid  

作　　者：Lu Cai Michael Horowitz Md Shahidul Islam 

机构地区：[1]Pediatric Research Institute,Department of Pediatrics,University of Louisville,Louisville,KY 40202,United States [2]Department of Medicine,University of Adelaide,Adelaide 5005,Australia [3]Department of Biochemistry,School of Life Sciences,University of KwaZulu-Natal,Durban 4000,KwaZulu-Natal,South Africa

出　　处：《World Journal of Diabetes》2023年第12期1717-1720,共4页世界糖尿病杂志（英文版）（电子版）

摘　　要：Uncontrolled hyperglycemia or poorly managed disease increases the propensityfor a number of diabetes-related complications targeting major organs includingthe heart, eyes, and kidney. Although the mechanisms by which diabetes inducescardiovascular diseases include oxidative stress and inflammation, when insulinresistance remains the key to the pathogenesis, as implicated in the two reviews inthis issue. This editorial mainly comments on the potential preventive applicationof glycyrrhetinic acid (or 18β-GA) in relation to diabetic nephropathy. The therapeuticor preventive effects of 18β-GA, as a hydrolytic product of glycy-rrhizicacid that is a component of licorice, have been appreciated in other disorders, buthave received much less attention in relation to diabetic complications. A study inthis issue has identified 18β-GA as a therapeutic for preventing diabeticnephropathy and provides evidence to support efficacy in cultured human renaltubule cells in vitro. Although it represents a pilot study, the observations supporta new therapeutic approach that warrants further ex-ploration.

关 键 词：Insulin resistance Diabetic cardiomyopathy Diabetic nephropathy Glycyrrhetinic acid LICORICE Chinese herbal remedy 

分 类 号：R587.1[医药卫生—内分泌] R692[医药卫生—内科学]