Relationship between GCKR gene rs780094 polymorphism and type 2 diabetes with albuminuria  

作　　者：Yi-Ying Liu Qin Wan 

机构地区：[1]Department of Endocrinology,Deyang People’s Hospital,Deyang 618000,Sichuan Province,China [2]Department of Endocrinology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000,Sichuan Province,China

出　　处：《World Journal of Diabetes》2023年第12期1803-1812,共10页世界糖尿病杂志（英文版）（电子版）

基　　金：the Key R&D Project of the Ministry of Science and Technology,No.2016YFC0901200 and 2016YFC0901205.

摘　　要：BACKGROUND Diabetic kidney disease is one of the common complications of type 2 diabetes(T2D).There are no typical symptoms in the early stage,and the disease will progress to moderate and late stage when albuminuria reaches a high level.Treatment is difficult and the prognosis is poor.At present,the pathogenesis of diabetic kidney disease is still unclear,and it is believed that it is associated with genetic and environmental factors.AIM To explore the relationship between the glucokinase regulatory protein(GCKR)gene rs780094 polymorphism and T2D with albuminuria.METHODS We selected 252 patients(126 males and 126 females)with T2D admitted to our hospital from January 2020 to October 2020,and 66 healthy people(44 females and 22 males).According to the urinary albumin/creatinine ratio,the subjects were divided into group I(control),group II(T2D with normoalbuminuria),group III(T2D with microalbuminuria),and group IV(T2D with macroalbuminuria).Additionly,the subjects were divided into group M(normal group)or group N(albuminuria group)according to whether they developed albuminuria.We detected the GCKR gene rs780094 polymorphism(C/T)of all subjects,and measured the correlation between GCKR gene rs780094 polymorphism(C/T)and T2D with albuminuria.RESULTS Gene distribution and genotype distribution among groups I-IV accorded with the Hardy-Weinberg equilibrium.Genotype frequency was significantly different among the four groups (P = 0.048, χ^(2)= 7.906). T allele frequency in groups II, III, and IV was significantly higherthan that in group I. Logistic regression analysis of the risk factors for T2D with albuminuria showed that the CT +TT genotype (odds ratio = 1.710, 95% confidence interval: 1.172-2.493) was a risk factor.CONCLUSION CT + TT genotype is a risk factor for T2D with albuminuria. In the future, we can assess the risk of individualscarrying susceptible genes to delay the onset of T2D.

关 键 词：Type 2 diabetes mellitus ALBUMINURIA Glucokinase regulatory protein rs780094 Gene polymorphism 

分 类 号：R587.2[医药卫生—内分泌]