Potential therapeutic targets for nonalcoholic fatty liver disease:Glucagon-like peptide 1  

作　　者：Yue-Hua Yin Li-Xuan Sang Bing Chang 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning Province,China [2]Department of Gastroenterology,Shengjing Hospital of China Medical University,Shenyang 110022,Liaoning Province,China

出　　处：《World Journal of Gastroenterology》2023年第48期6235-6238,共4页世界胃肠病学杂志（英文版）

摘　　要：Nonalcoholic fatty liver disease(NAFLD)is the most rapidly growing contributor to liver mortality and morbidity.Hepatocellular injury in nonalcoholic steatohepatitis(NASH)is caused by an increase in metabolic substrates(glucose,fructose,and fatty acids),leading fatty acids to participate in pathways that cause cellular injury and a poor response to injury.The pathogenesis of this disease is largely associated with obesity,type 2 diabetes,and increasing age.To date,there are no Food and Drug Administration-approved treatments for NAFLD/NASH or its associated fibrosis.Since one of the pathogenic drivers of NASH is insulin resistance,therapies approved for the treatment of type 2 diabetes are being evaluated in patients with NASH.Currently,the glucagon-like peptide-1 receptor agonist(GLP-1RA)semaglutide is a safe,well-studied therapeutic for NAFLD/NASH patients.Existing research demonstrates that semaglutide can increase the resolution of NASH but not improve fibrosis.However,improving the fibrosis of NAFLD is the only way to improve the long-term prognosis of NAFLD.Given the complex pathophysiology of NASH,combining therapies with complementary mechanisms may be beneficial.Researchers have conducted trials of semaglutide in combination with antifibrotic drugs.However,the results have not fully met expectations,and it cannot be ruled out that the reason is the short trial time.We should continue to pay increasing attention to GLP-1RAs.

关 键 词：Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Antidiabetic drugs Glucagon-like peptide 1 Semaglutide 

分 类 号：R575.5[医药卫生—消化系统]