Inflammatory bowel disease among first generation immigrants in Israel:A nationwide epi-Israeli Inflammatory Bowel Disease Research Nucleus study  

作　　者：Mira Stulman Gili Focht Yiska Loewenberg Weisband Shira Greenfeld Amir Ben Tov Natan Ledderman Eran Matz Ora Paltiel Shmuel Odes Iris Dotan Eric Ian Benchimol Dan Turner 

机构地区：[1]The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition,Shaare Zedek Medical Center,Faculty of Medicine,The Hebrew University of Jerusalem,Jerusalem 9103102,Israel [2]Braun School of Public Health and Community Medicine,Hadassah Medical Organization,Faculty of Medicine,Hebrew University of Jerusalem,Jerusalem 9574869,Israel [3]Clalit Research Institute,Tel Aviv 6209804,Israel [4]Maccabi Health Services and the Sackler Faculty of Medicine,Tel Aviv University,Tel Aviv 6801296,Israel [5]Meuhedet Health Services,Tel Aviv 6203854,Israel [6]Leumit Health Services,Tel Aviv 6473704,Israel [7]Faculty of Health Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel [8]Department of Gastroenterology,Rabin Medical Center,Petah Tikva 49100,Israel [9]Department of Paediatrics and Institute of Health Policy,Management and Evaluation,The Hospital for Sick Children,University of Toronto,Toronto M5G 1X8,ON,Canada [10]SickKids Inflammatory Bowel Disease Centre,Division of Gastroenterology,Hepatology and Nutrition,Child Health Evaluative Sciences,The Hospital for Sick Children and the SickKids Research Institute,Toronto M5G 1X8,Canada [11]ICES,Toronto M4N 3M5,Canada

出　　处：《World Journal of Methodology》2023年第5期475-483,共9页世界方法学杂志

摘　　要：BACKGROUND Israel has a high rate of Jewish immigration and a high prevalence of inflammatory bowel disease(IBD).AIM To compare IBD prevalence in first-generation immigrants vs Israel-born Jews.METHODS Patients with a diagnosis of IBD as of June 2020 were included from the validated epi-IIRN(Israeli IBD Research Nucleus)cohort that includes 98%of the Israeli population.We stratified the immigration cohort by IBD risk according to country of origin,time period of immigration,and age group as of June 2020.RESULTS A total of 33544 patients were ascertained,of whom 18524(55%)had Crohn’s disease(CD)and 15020(45%)had ulcerative colitis(UC);28394(85%)were Israel-born and 5150(15%)were immigrants.UC was more prevalent in immigrants(2717;53%)than in non-immigrants(12303,43%,P<0.001),especially in the<1990 immigration period.After adjusting for age,longer duration in Israel was associated with a higher point prevalence rate in June 2020(high-risk origin:Immigration<1990:645.9/100000,≥1990:613.2/100000,P=0.043;intermediate/low-risk origin:<1990:540.5/100000,≥1990:192.0/100000,P<0.001).The prevalence was higher in patients immigrating from countries with high risk for IBD(561.4/100000)than those originating from intermediate-/low-risk countries(514.3/100000;P<0.001);non-immigrant prevalence was 528.9/100000.CONCLUSION Lending support to the environmental effect on IBD etiology,we found that among immigrants to Israel,the prevalence of IBD increased with longer time since immigration,and was related to the risk of IBD in the country of origin.The UC rate was higher than that of CD only in those immigrating in earlier time periods.

关 键 词：EPIDEMIOLOGY Inflammatory bowel disease IMMIGRATION Environment 

分 类 号：R57[医药卫生—消化系统]