Serum omentin-1 is correlated with the severity of liver disease in patients with chronic hepatitis C  

作　　者：Georg Peschel Kilian Weigand Jonathan Grimm Martina Müller Christa Buechler 

机构地区：[1]Department of Internal Medicine I,University Hospital Regensburg,Regensburg 93053,Germany [2]Department of Internal Medicine,Klinikum Fürstenfeldbruck,Fürstenfeldbruck 82256,Germany [3]Department of Gastroenterology,Gemeinschaftsklinikum Mittelrhein,Koblenz 56073,Germany

出　　处：《World Journal of Hepatology》2023年第12期1315-1324,共10页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Patients with chronic hepatitis C virus(HCV)infection have increased serum omentin-1.Omentin-1 is an anti-inflammatory adipokine,and higher levels may be a direct effect of HCV infection.Successful elimination of HCV by direct acting antivirals almost normalized circulating levels of various molecules with a role in inflammation.AIM To evaluate the effect of HCV infection on serum omentin-1,serum omentin-1 levels of HCV patients were measured before therapy and at 12 wk after therapy end.Associations of serum omentin-1 with parameters of inflammation and liver function were explored at both time points.Serum omentin-1 levels of patients with and without liver cirrhosis,which was defined by ultrasound or the fibrosis-4(FIB-4)score,were compared.METHODS Serum omentin-1 levels were measured by enzyme-linked immunosorbent assay in 84 chronic HCV patients before therapy and at 12 wk after therapy end where sustained virological response 12(SVR12)was achieved in all patients.Serum omentin-1 of 14 non-infected controls was measured in parallel.RESULTS In patients with chronic HCV,serum omentin-1 levels were not related to viral load or viral genotype.HCV patients with liver steatosis and HCV patients with diabetes had serum omentin-1 levels comparable to patients not suffering from these conditions.Serum omentin-1 levels at SVR12 were similar in comparison to pretreatment levels.In addition,serum levels did not differ between HCV-infected patients and non-infected controls.Serum omentin-1 levels did not correlate with leukocyte count or C-reactive protein.Positive correlations of serum omentin-1 with bilirubin and the model for end-stage liver disease score(MELD)were detected before therapy and at SVR12 in the whole cohort.Bilirubin and the MELD score also positively correlated with serum omentin-1 levels in the subgroup of patients with ultrasound diagnosed liver cirrhosis before therapy.At SVR12,serum omentin-1 levels of patients with liver cirrhosis negatively correlated with albumin.Before therapy start,p

关 键 词：Direct acting antivirals Hepatitis C Liver cirrhosis ADIPOKINE 

分 类 号：R512.63[医药卫生—内科学]