Mutational separation and clinical outcomes of TP53 and CDH1 in gastric cancer  

作　　者：He-Li Liu Huan Peng Chang-Hao Huang Hai-Yan Zhou Jie Ge 

机构地区：[1]Department of Gastrointestinal Surgery,Xiangya Hospital,Central South University,Changsha 410008,Hunan Province,China [2]Clinical Nursing Teaching and Research Section,Xiangya Hospital,Central South University,Changsha 410008,Hunan Province,China [3]Teaching and Research Section of Clinical Nursing,Xiangya Hospital,Central South University,Changsha 410008,Hunan Province,China [4]Department of Pathology,Xiangya Hospital,Central South University,Changsha 410008,Hunan Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2023年第12期2855-2865,共11页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by Guangdong Yiyang Healthcare Charity Foundation,No.JZ2022014.

摘　　要：BACKGROUND Gastric cancer(GC)is a deadly tumor with the fifth highest occurrence and highest global mortality rates.Owing to its heterogeneity,the underlying mechanism of GC remains unclear,and chemotherapy offers little benefit to individuals.AIM To investigate the clinical outcomes of TP53 and CDH1 mutations in GC.METHODS In this study,202 gastric adenocarcinoma tumor tissues and their corresponding normal tissues were collected.A total of 490 genes were identified using target capture.Through t-test and Wilcoxon rank-sum test,somatic mutations,microsatellite instability,and clinical statistics,including overall survival,were detected,compared,and calculated.RESULTS The mutation rates of 32 genes,including TP53,SPEN,FAT1,and CDH1 exceeded 10%.TP53 mutations had a slightly lower overall occurrence rate(33%).The TP53 mutation rate was significantly higher in advanced stages(stage Ⅲ/Ⅳ)than that in early stages(stage Ⅰ/Ⅱ)(P<0.05).In contrast,CDH1 mutations were significantly associated with diffuse GC.TP53 is related to poor prognosis of advanced-stage tumors;nevertheless,CDH1 corresponds to a diffuse type of cancer.TP53 is exclusively mutated in CDH1 and is primarily affected by two distinct GC mechanisms.CONCLUSION Different somatic mutation patterns in TP53 and CDH1 indicate two major mechanisms of GC.

关 键 词：Gastric cancer TP53 mutation CDH1 mutation Clinical outcome Somatic mutation Diffuse gastric cancer 

分 类 号：R73[医药卫生—肿瘤]