Intensive follow-up vs conventional follow-up for patients with nonmetastatic colorectal cancer treated with curative intent:A metaanalysis  

作　　者：Li-Li Cui Shi-Qi Cui Zhong Qu Zhen-Qing Ren 

机构地区：[1]Department of Operating Room,Jiangsu Taizhou People’s Hospital,Taizhou 225300,Jiangsu Province,China [2]Department of Oncology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310020,Zhejiang Province,China [3]Department of Endoscopy Center,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310020,Zhejiang Province,China [4]Department of Nursing,Jiangsu Taizhou People’s Hospital,Taizhou 225300,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2023年第12期2197-2211,共15页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：BACKGROUND The frequency and content of follow-up strategies remain controversial for colorectal cancer(CRC),and scheduled follow-ups have limited value.AIM To compare intensive and conventional follow-up strategies for the prognosis of non-metastatic CRC treated with curative intent using a meta-analysis.METHODS PubMed,Embase,and the Cochrane Library databases were systematically searched for potentially eligible randomized controlled trials(RCTs)from inception until April 2023.The Cochrane risk of bias was used to assess the methodological quality of the included studies.The hazard ratio,relative risk,and 95%confidence interval were used to calculate survival and categorical data,and pooled analyses were performed using the random-effects model.Additional exploratory analyses were performed for sensitivity,subgroups,and publication bias.RESULTS Eighteen RCTs involving 8533 patients with CRC were selected for the final analysis.Intensive follow-up may be superior to conventional follow-up in improving overall survival,but this difference was not statistically significant.Moreover,intensive follow-up was associated with an increased incidence of salvage surgery compared to conventional follow-up.In addition,there was no significant difference in the risk of recurrence between intensive and conventional follow-up strategies,whereas intensive follow-up was associated with a reduced risk of interval recurrence compared to conventional follow-up.Finally,the effects of intensive and conventional follow-up strategies differed when stratified by tumor location and follow-up duration.CONCLUSION Intensive follow-up may have a beneficial effect on the overall survival of patients with non-metastatic CRC treated with curative intent.

关 键 词：Intensive follow-up Conventional follow-up Colorectal cancer Curative intent Meta-analysis 

分 类 号：R73-37[医药卫生—肿瘤]