Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy  

作　　者：Jin Li Wen-Huan Xiao Fei Ye Xiao-Wei Tang Qiu-Fang Jia Xiao-Bin Zhang 

机构地区：[1]Department of Psychiatry,The Affiliated Guangji Hospital of Soochow University,Suzhou 215137,Jiangsu Province,China [2]Department of Psychiatry,Affiliated Wutaishan Hospital of Medical College of Yangzhou University,Yangzhou 225000,Jiangsu Province,China

出　　处：《World Journal of Psychiatry》2023年第12期995-1004,共10页世界精神病学杂志

基　　金：Supported by This study was supported by the Suzhou Municipal Sci-Tech Bureau Program,No.SS202070;Scientific and Technological Program of Suzhou,No.SS202069;Suzhou clinical Medical Center for mood disorders,No.Szlcyxzx202109;Suzhou Clinical Key Disciplines for Geriatric Psychiatry,No.SZXK202116;Suzhou Key Technologies Program,No.SKY2021063;Jiangsu Province social development project,No.BE2020764;Research Project of Jiangsu Commission of Health,No.M2020031;Elderly Health Research Project of Jiangsu Commission of Health,No.LR2022015 and No.LKZ2023020.

摘　　要：BACKGROUND There are systematic differences in clinical features between women and men with schizophrenia(SCZ).The regulation of sex hormones may play a potential role in abnormal neurodevelopment in SCZ.Brain-derived neurotrophic factor(BDNF)and sex hormones have complex interacting actions that contribute to the etiology of SCZ.AIM To investigate the influence of BDNF and sex hormones on cognition and clinical symptomatology in chronic antipsychotic-treated male SCZ patients.METHODS The serum levels of follicle-stimulating hormone,luteinizing hormone(LH),estradiol(E2),progesterone,testosterone(T),prolactin(PRL)and BDNF were compared between chronic antipsychotic-treated male(CATM)patients with SCZ(n=120)and healthy controls(n=120).The Positive and Negative Syndrome Scale was used to quantify SCZ symptoms,while neuropsychological tests were used to assess cognition.Neuropsychological tests,such as the Digit Cancellation Test(DCT),Semantic Verbal Fluency(SVF),Spatial Span Test(SS),Paced Auditory Serial Addition Test(PASAT),Trail Making Task(TMT-A),and Block Design Test(BDT),were used to assess executive functions(BDT),attention(DCT,TMT-A),memory(SS,PASAT),and verbal proficiency(SVF).RESULTS Although E2 levels were significantly lower in the patient group compared to the healthy controls,T,PRL,and LH levels were all significantly higher.Additionally,the analysis revealed that across the entire sample,there were positive correlations between E2 Levels and BDNF levels as well as BDNF levels and the digital cancellation time.In CATM patients with SCZ,a significant correlation between the negative symptoms score and PRL levels was observed.CONCLUSION Sex hormones and BDNF levels may also be linked to cognitive function in patients with chronic SCZ.

关 键 词：Brain-derived neurotrophic factor Clinical symptoms Cognitive function SCHIZOPHRENIA Sex hormones 

分 类 号：R749.3[医药卫生—神经病学与精神病学]