Focus on limbal stem cell deficiency and limbal cell transplantation  

作　　者：Emanuele Tonti Gregorio Antonio Manco Leopoldo Spadea Marco Zeppieri 

机构地区：[1]Eye Clinic,Policlinico Umberto I,"Sapienza"University of Rome,Rome 00142,Italy [2]Department of Ophthalmology,University Hospital of Udine,Udine 33100,Italy

出　　处：《World Journal of Transplantation》2023年第6期321-330,共10页世界移植杂志

摘　　要：Limbal stem cell deficiency(LSCD)causes severe vision impairment and can lead to blindness,representing one of the most challenging ocular surface disorders.Stem cell deficiency can be congenital or,more often,acquired.The categorization of ocular surface transplantation techniques is crucial to achieving treatment homogeneity and quality of care,according to the anatomic source of the tissue being transplanted,genetic source,autologous or allogenic transplantation(to reflect histocompatibility in the latter group),and cell culture and tissue engineering techniques.The aim of this minireview is to provide a summary of the management of LSCD,from clinical characteristics and therapeutic outcomes to the development of novel therapeutic approaches.The manuscript also briefly summarizes recent findings in the current literature and outlines the future challenges to overcome in the management of the major types of ocular surface failure.

关 键 词：Limbal stem cell deficiency Conjunctival limbal autograft Conjunctival limbal allograft Keratolimbal allograft Cultivated limbal epithelial transplantation Simple limbal epithelial transplantation 

分 类 号：R73[医药卫生—肿瘤]