代谢组学技术结合机器学习算法在损伤时间推断中的研究进展  

Research Progress of Metabolomics Techniques Combined with Machine LearningAlgorithm in Wound Age Estimation

作　　者：马星宇 程浩 张忠铎 李烨铭 赵东 MA Xing-yu;CHENG Hao;ZHANG Zhong-duo;LI Ye-ming;ZHAO Dong(Collaborative Innovation Center of Judicial Civilization,Key Laboratory of Evidence Science,Ministry of Education,China University of Political Science and Law,Beijing 100088,China;Department of Foren-sic Pathology,School of Forensic Medicine,China Medical University,Shenyang 110122,China;Key Laboratory of Forensic Genetics,Ministry of Public Security,Institute of Forensic Science,Ministry of Pub-lic Security,Beijing 100038,China)

机构地区：[1]中国政法大学证据科学教育部重点实验室司法文明协同创新中心,北京100088 [2]中国医科大学法医学院法医病理学教研室,辽宁沈阳110122 [3]公安部鉴定中心法医遗传学公安部重点实验室,北京100038

出　　处：《法医学杂志》2023年第6期596-600,共5页Journal of Forensic Medicine

基　　金：国防基础科研计划资助项目(JCKY2021601B021)。

摘　　要：损伤时间推断是法医学实践中的重要内容,准确推断损伤时间是国内外法医学者亟待解决的科学问题。代谢组学技术可以有效检测机体受到体内外刺激因素作用产生的内源性代谢物,描述生物体内代谢物的动态变化,具有操作性强、检测效率高、定量结果 准确等优势。机器学习算法对高维数据集的处理具有独特优势,能够有效挖掘生物信息,真实反映机体生理、疾病或损伤状态,是高效处理高通量大数据的新型技术手段。本文综述了代谢组学技术与机器学习算法的研究现状和自身优势,探讨应用代谢组学技术结合机器学习算法在法医学损伤时间推断研究中的应用前景,为法医学损伤时间推断研究提供新思路。Wound age estimation is the core content in the practice of forensic medicine.Accurate esti‐mation of wound age is a scientific question that needs to be urgently solved by forensic scientists at home and abroad.Metabolomics techniques can effectively detect endogenous metabolites produced by internal or external stimulating factors and describe the dynamic changes of metabolites in vivo.It has the advantages of strong operability,high detection efficiency and accurate quantitative results.Machine learning algorithm has special advantages in processing high-dimensional data sets,which can effec‐tively mine biological information and truly reflect the physiological,disease or injury state of the body.It is a new technical means for efficiently processing high-throughput big data.This paper re‐views the status and advantages of metabolomic techniques combined with machine learning algorithm in the research of wound age estimation,and provides new ideas for this research.

关 键 词：法医学 代谢组学 机器学习 损伤时间推断 综述 

分 类 号：R89[医药卫生—法医学] DF795.1[医药卫生—临床医学] D919.1[政治法律—诉讼法学]