载脂蛋白M与癌症  

Apolipoprotein M and cancer

作　　者：李华珊 李文静[1] 罗光华(综述)[2] 薛海翔(审校) LI Huashan;LI Wenjing;LUO Guanghua;XUE Haixiang(Department of Otolaryngology,Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213000;General Laboratory,Third Affiliated Hospital of Soochow University,Changzhou Jiangsu 213000,China)

机构地区：[1]苏州大学第三附属医院耳鼻咽喉科,江苏常州213000 [2]苏州大学第三附属医院综合实验室,江苏常州213000

出　　处：《临床与病理杂志》2023年第10期1838-1847,共10页Journal of Clinical and Pathological Research

基　　金：常州市应用基础研究计划(CJ20220106)。

摘　　要：载脂蛋白M(apolipoprotein M,APOM)属于载脂蛋白家族,主要分布于高密度脂蛋白颗粒中,可增强高密度脂蛋白中胆固醇的抗氧化能力,也可参与胆固醇逆转运,起抗动脉粥样硬化作用。APOM也与2型糖尿病、肥胖和炎症性疾病等多种疾病密切相关,可协同转录因子、细胞因子及激素调控上述疾病的发展和转归。APOM与多种肿瘤如肝癌、肾癌、结直肠癌、乳腺癌、肺癌和喉癌的发生和发展有关,其机制涉及维生素D受体(vitamin D receptor,VDR)、Yes相关蛋白(Yes-associated protein,YAP)、胱天蛋白酶等在内的多种信号通路。然而,APOM在不同的癌症中,甚至在同一种癌症的不同进程中的作用并不统一,具有促癌和抑癌的双面性。明晰APOM在肿瘤中的功能和作用机制,有望为肿瘤的治疗提供新的策略。Apolipoprotein M(APOM)belongs to the apolipoprotein family,primarily distributed in high-density lipoprotein(HDL)particles.It enhances the antioxidant capacity of cholesterol in HDLs and participates in cholesterol reverse transport,playing a role in anti-atherosclerosis.Additionally,APOM is associated with various diseases,including type 2 diabetes,obesity,and inflammatory conditions.It collaborates with transcription factors,cytokines,and hormones to regulate the development and outcomes of these diseases.Recent studies have found that APOM is related to the occurrence and progression of various cancers,such as liver cancer,kidney cancer,colorectal cancer,breast cancer,lung cancer,and laryngeal cancer The mechanisms involve multiple signaling pathways,including vitamin D receptor(VDR),Yes-associated protein(YAP)and caspase.However,the role of APOM is not consistent across different cancers or even within different stages of the same cancer,exhibiting a dual role in promoting and inhibiting cancer.Clarifying the functions and mechanisms of APOM in tumors is expected to provide a new strategy for tumor treatment.

关 键 词：载脂蛋白M 肝癌 肾癌 结直肠癌 乳腺癌 肺癌 喉癌 

分 类 号：R730.5[医药卫生—肿瘤]