成纤维细胞活化蛋白在肿瘤诊断及治疗中的研究进展  

Research progress of fibroblast activation protein in tumors diagnosis and treatment

作　　者：李菀婷 吴颖彤 郑黔莉 王檬 田张瑶 田林露 钱滢滢(综述) 杨文利(审校) LI Wanting;WU Yingtong;ZHENG Qianli;WANG Meng;TIAN Zhangyao;TIAN Linlu;QIAN Yingying;YANG Wenli(Department of Human Anatomy and Histology and Embryology,Basic Teaching,Zhuhai Campus of Zunyi Medical University,Zhuhai Guangdong 519041,China)

机构地区：[1]遵义医科大学珠海校区基础教学部人体解剖学与组织胚胎学教研室,广东珠海519041

出　　处：《临床与病理杂志》2023年第10期1848-1856,共9页Journal of Clinical and Pathological Research

基　　金：贵州省大学生创新创业项目(S202210661013);遵义医科大学博士科研基金(F-ZH-09);遵义医科大学珠海校区大学生创新创业项目(ZHCX202113,ZHCX2022039)。

摘　　要：成纤维细胞活化蛋白(fibroblast activation protein,FAP)是肿瘤相关成纤维细胞(carcinoma-associated fibroblasts,CAFs)的特异性标志物之一,在正常组织和非恶性肿瘤中基本不表达,但在绝大多数的上皮细胞来源的恶性肿瘤CAFs中高表达。FAP具有肿瘤细胞恶性生物学相关表型的功能,可作为特异性的肿瘤标志物,在肝细胞癌(hepatocellular carcinoma,HCC)、胰腺癌、乳腺癌和口腔癌等肿瘤的临床诊疗方面具有较高的研究价值。针对FAP的靶向治疗策略有FAP抑制剂(FAP inhibition,FAPI)、FAP酶激活式前体药物、FAP疫苗、FAP抗体和嵌合抗原受体T细胞免疫治疗(chimeric antigen receptor T cell immuno-therapy,CAR-T)等,其作用机制主要体现在:1)靶向抑制FAP活性从而抑制肿瘤生长;2)消除基质-肿瘤细胞间的相互作用(尤其在实体瘤中),增加肿瘤内药物传递,促进免疫治疗药物的活性。FAP在肿瘤诊断及治疗中的研究,可为相关的临床研究提供参考价值,并协助提高临床上肿瘤的诊治效率及患者的生活质量,延长总生存期及减少并发症。Fibroblast activation protein(FAP)is one of the specific markers of carcinoma-associated fibroblasts(CAFs),which is generally not expressed in normal tissues and non-malignant tumors but is highly expressed in CAFs derived from the majority of malignant tumors of epithelial cell origin.FAP can be used as a specific tumor marker and has a high research value in the clinical diagnosis and treatment of hepatocellular carcinoma(HCC),pancreatic cancer,breast cancer,and oral cancer.Targeted treatment strategies for FAP include FAP inhibition,FAPI),FAP enzyme-activated prodrugs,FAP vaccines,FAP antibodies and chimeric antigen receptor T cell immuno-therapy(CAR-T).Their mechanisms of action are mainly reflected in:1)Targeted inhibition of FAP activity to suppress tumor growth;2)eliminate stroma-tumor cell interactions,especially in solid tumors,to increase intratumoral drug delivery and enhance the activity of immunotherapy drugs.The study of FAP in the diagnosis and treatment of tumors can provide reference value for related clinical research,and help to improve the efficiency of clinical diagnosis and treatment of tumors and the quality of life of patients,prolong the overall survival and reduce complications.

关 键 词：成纤维细胞活化蛋白 肿瘤 诊断 治疗 

分 类 号：R730.5[医药卫生—肿瘤]