慢性应激对肿瘤发生发展影响的研究进展  

Advances in the effect of chronic stress on the occurrence and development of tumor

作　　者：乔怡倩 穆华[2] 赵武杰(综述)[1] 贾漪涛(审校)[1] QIAO Yiqian;MU Hua;ZHAO Wujie;JIA Yitao(Third Department of Oncology,Hebei General Hospital,Shijiazhuang 050051,Hebei,China;Outpatient Office,Hebei General Hospital,Shijiazhuang 050051,Hebei,China)

机构地区：[1]河北省人民医院肿瘤三科,石家庄050051 [2]河北省人民医院门诊办,石家庄050051

出　　处：《医学研究与战创伤救治》2023年第8期883-887,共5页Journal of Medical Research & Combat Trauma Care

基　　金：河北省自然科学基金资助项目(H2022307056)。

摘　　要：在疾病进展等多种应激原的刺激下,肿瘤患者极易发生慢性应激。慢性应激通过持续激活交感神经系统和下丘脑-垂体-肾上腺轴,导致机体神经内分泌功能紊乱和肠道菌群失调,影响肿瘤进展过程中的多个步骤。对患者进行心理干预以及药物治疗等,可能会有效改善患者生存质量,提高抗肿瘤治疗效果。文章就慢性应激对肿瘤发生发展的影响及相关干预措施作一综述。Under the stimulation of various stressors such as disease progression,cancer patients are prone to chronic stress.Chronic stress can continuously activate the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis,leading to neuroendocrine dysfunction and imbalance ofintestinal flora,and affecting multiple steps in the process of tumor progression.Psychological intervention and drug therapy may effectively improve the quality of life of patients and improve the effect of anti-tumor therapy.This article reviews the effects of chronic stress on the occurrence anddevelopment of tumor and the relevant intervention measures.

关 键 词：慢性应激 肿瘤 神经内分泌 心理行为干预 

分 类 号：R730[医药卫生—肿瘤]