豁痰开窍汤联合温针治疗痰浊阻窍型血管性痴呆临床研究  

Clinical Study on Huotan Kaiqiao Decoction Combined with Warm Needling for Vascular Dementia of Phlegm Turbidity Obstructing the Orifices Type

作　　者：尚官红 关荣杓 常丹阳 常晓 SHANG Guanhong;GUAN Rongbiao;CHANG Danyang;CHANG Xiao(Department of Rehabilitation,Nanyang Zhangzhongjing Hospital,Nanyang Henan 473000,China;Henan University of Chinese Medicine,Zhengzhou Henan,450000;Department of Encephalopathy,Nanyang Zhangzhongjing Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳张仲景医院康复科,河南南阳473000 [2]河南中医药大学,河南郑州450000 [3]南阳张仲景医院脑病科,河南南阳473000

出　　处：《新中医》2023年第23期76-80,共5页New Chinese Medicine

基　　金：河南省中医药青苗人才培养项目(豫卫中医函〔2021〕16号)。

摘　　要：目的:观察豁痰开窍汤联合温针治疗痰浊阻窍型血管性痴呆(VD)的临床疗效。方法:选取痰浊阻窍型VD患者86例,按随机数字表法分为对照组和联合组各43例,每组各脱落3例。对照组给予常规西药治疗,联合组在对照组基础上辅以豁痰开窍汤联合温针治疗,连续治疗3个月。评价2组临床疗效,比较2组治疗前后中医证候积分、认知功能、日常生活能力评分、血清指标。结果:联合组总有效率为90.00%,高于对照组70.00%(P<0.05)。治疗后,2组主症、次症积分均较治疗前降低(P<0.05),且联合组主症、次症积分均低于对照组(P<0.05)。治疗后,2组认知功能、日常生活能力评分较较治疗前升高(P<0.05),且联合组认知功能、日常生活能力评分均高于对照组(P<0.05)。治疗后,2组血清白细胞介素-18(IL-18)、同型半胱氨酸(Hcy)、血管内皮生长因子(VEGF)水平均较治疗前降低,且联合组血清IL-8、Hcy、VEGF水平均低于对照组(P<0.05);2组血清脑源性神经营养因子(BDNF)水平较治疗前升高,且联合组BDNF水平高于对照组(P<0.05)。结论:豁痰开窍汤联合温针治疗痰浊阻窍型VD能够改善患者临床症状,提高患者认知功能和日常活动能力,降低炎症反应,促进神经功能恢复。Objective:To observe the clinical effect of Huotan Kaiqiao Decoction combined with warm needling on vascular dementia(VD)of phlegm turbidity obstructing the orifices type.Methods:A total of 86 cases of VD patients of phlegm turbidity obstructing the orifices type were selected and divided into the control group and the combination group according to different treatment methods,with 43 cases in each group,and 3 cases dropped out in each group.The control group was treated with routine western medicine,and the combination group was additionally treated with Huotan Kaiqiao Decoction combined with warm needling based on the treatment of the control group.Both groups were continuously treated for 3 months.Clinical effects were evaluated in the two groups.Traditional Chinese medicine syndrome scores,the scores of cognitive function and activities of daily living,and serum indicators were compared between the two groups before and after treatment.Results:The total effective rate was 90.00%in the combination group,higher than that of 70.00%in the control group(P<0.05).After treatment,the scores of main symptoms and secondary symptoms in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of main symptoms and secondary symptoms in the combination group were lower than those in the control group(P<0.05).After treatment,the scores of cognitive function and activities of daily living in the two groups were increased when compared with those before treatment(P<0.05),and the above scores in the combination group were higher than those in the control group(P<0.05).After treatment,the levels of interleukin-18(IL-18),homocysteine(Hcy),and vascular endothelial growth factor(VEGF)in serum in the two groups were decreased when compared with those before treatment,and the above three levels in the combination group were lower than those in the control group(P<0.05).The levels of brain derived neurotrophic factor(BDNF)in serum in the two groups were increased when compared with those before t

关 键 词：血管性痴呆 痰浊阻窍型 豁痰开窍汤 温针 中医证候积分 认知功能 日常生活能力 

分 类 号：R749.1[医药卫生—神经病学与精神病学]