三穴五针联合肺康复训练治疗脑卒中并发肺部感染临床研究  

Clinical Study on Three-Point and Five-Needling Method Combined with Pulmonary Rehabilitation Training for Cerebral Apoplexy Complicated with Pulmonary Infection

作　　者：郭延芳 贺春侠 冯学伟[1] GUO Yanfang;HE Chunxia;FENG Xuewei(Department of Rehabilitation,People's Hospital of Zhengzhou,Zhengzhou Henan 445000,China)

机构地区：[1]郑州人民医院康复医学科,河南郑州450000

出　　处：《新中医》2023年第23期174-179,共6页New Chinese Medicine

基　　金：河南省医学科技攻关计划项目(LHGJ20200692);河南省中医药科学研究专项课题(2022ZY1184)。

摘　　要：目的:观察三穴五针联合肺康复训练对脑卒中并发肺部感染后体液免疫、表面活性蛋白和抗炎介质的影响。方法:选取120例脑卒中并发肺部感染患者,按随机数字表法分为对照组和针刺组各60例。2组均采取基础对症治疗,对照组在基础对症治疗上行肺康复训练,针刺组在对照组基础上行三穴五针疗法。2组均以7 d为1个疗程,共治疗2个疗程。评价2组临床疗效,比较2组治疗前后免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、C3补体、C4补体、肺表面活性蛋白D(SP-D)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)水平,观察2组治疗前后的临床症状和体征。结果:针刺组总有效率为96.67%,高于对照组86.67%(P<0.05)。治疗后,2组症状和体征积分较治疗前降低(P<0.05),且针刺组症状和体征积分低于对照组(P<0.05)。2组血清IgA、IgG、C3、C4水平较治疗前升高(P<0.05),且针刺组血清IgA、IgG、C3、C4水平高于对照组(P<0.05)。治疗后,2组血清IL-4、IL-10较治疗前升高,SP-D水平较治疗前降低(P<0.05);且针刺组血清IL-4、IL-10水平高于对照组,SP-D水平低于对照组(P<0.05)。针刺组住院时间短于对照组(P<0.05)。结论:三穴五针联合肺康复训练治疗脑卒中并发肺部感染患者能提高疗效,增强机体体液免疫功能,降低肺表面活性蛋白表达,减轻机体炎症反应,改善缺氧情况。Objective:To observe the effect of three-point and five-needling method combined with pulmonary rehabilitation training on humoral immunity,surfactant protein and anti-inflammatory mediators in patients after cerebral apoplexy complicated with pulmonary infection.Methods:A total of 120 cases of patients with cerebral apoplexy complicated with pulmonary infection were selected and divided into the control group and the acupuncture group according to the random number table method,with 60 cases in each group.Both groups were treated with basic symptomatic treatment;the control group was additionally treated with pulmonary rehabilitation training,and the acupuncture group was additionally treated with three-point and five-needling method based on the treatment of the control group.Both groups were treated for two courses,with 7 days being a course.The clinical effects in the two groups were evaluated;the levels of immunoglobulin A(IgA),immunoglobulin G(IgG),C3 complement,C4 complement,pulmonary surfactant protein D(SP-D),interleukin-4(IL-4),and interleukin-10(IL-10)were compared before and after treatment between the two groups.The clinical symptoms and signs in the two groups were observed before and after treatment.Results:The total effective rate was 96.67%in the acupuncture group,higher than that of 86.67%in the control group(P<0.05).After treatment,the scores of symptoms and signs in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of symptoms and signs in the acupuncture group were lower than those in the control group(P<0.05).After treatment,the levels of IgA,IgG,C3,and C4 in the two groups were increased when compared with those before treatment(P<0.05),and the levels of IgA,IgG,C3,and C4 in the acupuncture group were higher than those in the control group(P<0.05).After treatment,the levels of IL-4 and IL-10 in serum in the two groups were increased when compared with those before treatment,and the levels of SP-D were decreased when compared with those before tre

关 键 词：脑卒中 肺部感染 肺康复训练 三穴五针 体液免疫 表面活性蛋白 抗炎介质 

分 类 号：R743.3[医药卫生—神经病学与精神病学]