三联方案与四联方案在根除难治性H.pylori感染中的效果对比分析  

Comparative Analysis of Efficacy of Triple and Quadruple Regimens in Eradicating Refractory H.Pylori Infection

作　　者：金玉琳[1] JIN Yulin(Department of Gastroenterology,Gaoyou Hospital of Traditional Chinese Medicine,Gaoyou,Jiangsu Province,225600 China)

机构地区：[1]高邮市中医医院消化内科,江苏高邮225600

出　　处：《中外医疗》2023年第33期75-78,共4页China & Foreign Medical Treatment

摘　　要：目的 探究三联方案与四联方案在根除难治性幽门螺杆菌(helicobacter pylori, HP)感染中的效果对比分析。方法 便利选取2021年1月—2022年12月高邮市中医医院消化内科收治的98例难治性HP感染患者为研究对象,按照随机数表法分为对照组和观察组,各49例。对照组采用三联方案治疗,观察组采用四联方案治疗。比较两组患者的根治率、炎性因子水平、症状积分、不良反应发生率。结果 采用符合方案分析(per-protocol analysis, PP)方法和意向性治疗分析(intention to treat analysis, ITT)方法可知,观察组的根治率均高于对照组,但差异无统计学意义(P>0.05)。治疗后,观察组反酸暖气(0.91±0.10)分、腹痛(0.87±0.15)分、腹胀(0.92±0.09)分等症状积分及肿瘤坏死因子-α(tumor necrosis factor, TNF-α)、血清降钙素原(procalcitonin, PCT)、白介素-8(interleukin-8, IL-8)水平均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 三联方案和四联方案根治难治性HP感染均可发挥一定的疗效,四联方案相较于三联方案可更好地降低患者的炎症因子水平,改善患者的临床症状,综合考虑采用四联该方案的优势性更高。Objective To explore the comparative analysis of the effect of triple and quadruple regimens in eradicating refractory Helicobacter pylori(HP)infection.Methods A total of 98 patients with refractory HP infection admitted to gastroenterology Department of Gaoyou Hospital of Traditional Chinese Medicine from January 2021 to December 2022 were conveniently selected as the study objects,and were divided into control group and observation group ac-cording to random number table method,with 49 cases in each group.The control group was treated with triple therapy,and the observation group was treated with quadruple therapy.The radical treatment rate,inflammatory factor level,symptom score and incidence of adverse reactions were compared between the two groups.Results By using per-protocol analysis(PP)and intention to treat analysis(ITT),the radical treatment rate of the observation group was higher than that of the control group,but there was no significant difference(P>0.05).After treatment,the symptom scores of acid reflux heating(0.91±0.10)points,abdominal pain(0.87±0.15)points,abdominal distention(0.92±0.09)points in the observation group,and the levels of tumor necrosis factor(TNF-α),procalcitonin(PCT)and interleukin-8(IL-8)in serum were all lower than those in control group,the difference was statistically significant(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Both triple com-bination regimen and quadruple combination regimen can play a certain curative effect in the radical treatment of re-fractory HP infection.Compared with triple combination regimen,quadruple combination regimen can better reduce the level of inflammatory factors in patients and improve the clinical symptoms of patients.

关 键 词：三联方案 四联方案 难治性HP感染 呋喃唑酮 枸橼酸铋钾 

分 类 号：R573.1[医药卫生—消化系统]