Oral administration of Bacillus coagulans TQ-35 alleviates allergic responses in OVA-sensitive BALB/c mice  

作　　者：Yifan Wang Shanjun Chen Chong Wang Yi Zhang Hongliang Zeng Linglin Fu Yanbo Wang 

机构地区：[1]Food Safety Key Laboratory of Zhejiang Province,School of Food Science and Biotechnology,Zhejiang Gongshang University,Hangzhou 310018,China [2]College of Food Science,Fujian Agriculture and Forestry University,Fuzhou 350002,China [3]School of Food and Health,Beijing Technology and Business University,Beijing 100048,China

出　　处：《Food Science and Human Wellness》2024年第3期1246-1257,共12页食品科学与人类健康（英文）

基　　金：financially supported by the National Key R&D Program of China (2019YFC1605003);the Zhejiang Provincial Natural Science Foundation of China (LGN21C200013)。

摘　　要：Bacillus coagulans has been extensively studied so far,but there has been a lack of research on its usage in allergy.In this study,we designed to assess the effect of different concentrations of B.coagulans on food allergy in a BALB/c mouse model of ovalbumin(OVA)-induced food allergy and its effect on gut microbes.The assessment of symptoms,specific immunoglobulin E(IgE),T-cell differentiation,and related gene expression levels in sensitized mice by assay indicated that high doses of oral B.coagulans could alleviate allergic symptoms.Treatment with B.coagulans,in the high-dose group,significantly reduced IgE and IgG1 levels and modulated the balance of T helper type 1 cell(Th1)and Th2 and the expression of relevant genes in the spleen.16S rRNA analysis showed that probiotics improved the structure of the microbiota,in particular by boosting the percentage of Clostridia,Bacteroides vulgatus and Enterococcus faecium,and by increasing the abundance of microbial species,thereby modulating the immune system.Therefore,this study can provide insights into the practical application of B.coagulans doses to alleviate OVA allergy.

关 键 词：Bacillus coagulans TQ-35 Food allergy Ovalbumin(OVA) Gut microbiota 

分 类 号：TS201.6[轻工技术与工程—食品科学]