Influence of soaking Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China  

作　　者：Hui Nie Zhongyang Gao Yanghe Luo Yajuan Wang Feiyang Wu Guangqing Mu Xiaomeng Wu 

机构地区：[1]School of Food Science and Technology,Dalian Polytechnic University,Dalian 116034,China [2]Dalian Probiotic Function Research Key Laboratory,Dalian Polytechnic University,Dalian 116034,China [3]Guangxi Key Laboratory of Health Care Food Science and Technology,Hezhou University,Hezhou 542899,China

出　　处：《Food Science and Human Wellness》2024年第3期1311-1321,共11页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China (32072193);the Natural Science Foundation of Guangxi,China (2020GXNSFBA297083)。

摘　　要：To investigate the effects of drinking the soaking of Malus domeri(Bois)Chev.leaves on gut microbiota and metabolites of long-living elderly individuals in Hezhou city,Guangxi,China.It has been reported that longevity is closely related to metabolism and the gut microbiota.The 16S rRNA sequencing and liquid chromatography-mass spectrometry(LC-MS)were used to analysis fecal samples and explore the factors affecting longevity in the region.Interestingly,we discovered,that elderly individuals who had been drinking the soaking of M.domeri(Bois)Chev.leaves for a long time exhibited higher diversity of the gut microbiota than without drinking the soaking,notably.The proportions of Ruminococcaceae and Prevotella were decreased in those who did not drink this soaking.In addition,a total of 106 metabolites were characterized,and the people of long-lived people(>90 years old)and elderly people(<90 years old)who drinking soaking of M.domeri(Bois)Chev.leaves significantly altered the gut microbiota and upregulated levels of haplopine,farnesol,genipic acid,momordicinin,2-hydroxyestrone,hydroxyphenyllactic acid,caffeic acid,sophoraflavanone B,and soyasaponin I.We preliminarily determined that M.domeri(Bois)Chev.leaves consumption may be an important factor affecting longevity in this area.

关 键 词：LONGEVITY Malus domeri(Bois)Chev.leaves Gut microbiota Metabolomics 

分 类 号：TS201.4[轻工技术与工程—食品科学]