Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice  

作　　者：Xin Wang Weiye Xiu Ye Han Zhili Wang Yu Luo Yongqiang Ma 

机构地区：[1]Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources,College of Food Engineering,Harbin University of Commerce,Harbin 150028,China

出　　处：《Food Science and Human Wellness》2024年第3期1543-1555,共13页食品科学与人类健康（英文）

基　　金：financially supported by the Doctoral Scientific Research Start-up Foundation of the Harbin University of Commerce (2019DS098);the Young Innovation Talents Project from the Harbin University of Commerce (2019CX31);the Graduate Innovation Fund from the Harbin University of Commerce (YJSCX2019–615HSD)。

摘　　要：Type 2 diabetes mellitus(T2DM)is a metabolic disease caused by a glycolipid metabolism disorder and isletβ-cell dysfunction.SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob,an agricultural byproduct.The hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this study.SCP-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice,as well as decrease serum leptin and increase adiponectin secretion.Interestingly,real time-polymerase chain reaction(RT-PCR)and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins,including 5'-AMP-activated protein kinase(AMPK),carnitine palmitoyltransferase I(CPTI),and acetyl coenzyme A carboxylase(ACC)in the liver and AMPK,sirtuin1(Sirtl),peroxisome proliferator-activated receptorycoactivator-1(PGC-1α),and uncoupling protein 2(UCP2)in the pancreas.To have a hypoglycemic effect,SCP-80-1 regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/AC C/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1αand AMPK/Sirtl/UCP2 signaling pathways.These findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.

关 键 词：Sweet corn cob polysaccharide Type 2 diabetes Signal pathway 5’-AMP-activated protein kinase(AMPK) 

分 类 号：TS201.4[轻工技术与工程—食品科学]