PXN和PARK7蛋白在胃癌患者组织中的表达及其与临床预后的关系  

Expressions of PXN and PARK7 Proteins in Gastric Cancer Tissues andTheir Relationships with Clinical Prognosis

作　　者：熊丽丽 姬劲峰 袁妙兰 黄萍 朱向琥 XIONG Lili;JI Jinfeng;YUAN Miaolan;HUANG Ping;ZHU Xianghu(Department of pharmacy,2.Department of Clinical Nutrition,3.Department of Gerontology,4.Department of General Surgery,Zhongshan Fifth People’s Hospital,Zhongshan 528415,China)

机构地区：[1]中山市第五人民医院药学部,广东中山528415 [2]中山市第五人民医院临床营养科,广东中山528415 [3]中山市第五人民医院老年科,广东中山528415 [4]中山市第五人民医院普外科,广东中山528415

出　　处：《标记免疫分析与临床》2023年第10期1706-1711,共6页Labeled Immunoassays and Clinical Medicine

基　　金：中山市社会公益科技研究项目(编号:2022B1081)。

摘　　要：目的探究桩蛋白(PXN)和帕金森病蛋白7(PARK7)蛋白在胃癌患者组织中的表达及其与临床预后的关系。方法选取2018年1月至2020年1月期间于本院接受手术治疗的90例胃癌患者在术中切除的胃癌组织及相应癌旁组织;采用免疫组化法检测胃癌组织和癌旁组织中PXN和PARK7蛋白表达;采用Kaplan-Meier生存曲线和log-rank检验分析PXN和PARK7与预后的关系;采用Cox回归分析影响胃癌患者预后的危险因素。结果胃癌组织中PXN和PARK7蛋白阳性表达率显著高于癌旁组织(P<0.05)。胃癌组织中PXN和PARK7阳性表达与TNM分期、分化程度、淋巴结转移和浸润深度有关(P<0.05)。根据Kaplan-Meier法分析结果显示,胃癌组织PXN阳性表达患者3年生存率低于阴性表达患者(χ^(2)=5.034,P<0.05);胃癌组织PARK7阳性表达患者3年生存率低于阴性表达患者(χ^(2)=4.837,P<0.05)。根据Cox回归分析表明,PXN阳性表达、PARK7阳性表达、TNM分期、分化程度、淋巴结转移和浸润深度是影响胃癌患者预后的危险因素(P<0.05)。结论胃癌患者癌组织中PXN和PARK7蛋白表达显著升高,二者与临床病理特征以及预后密切相关。Objective To investigate expressions of Paxillin(PXN)and Parkinson’s disease protein 7(PARK7)in gastric cancer tissues and their relationships with clinical prognosis.Methods Ninety gastric cancer patients who underwent surgical treatment in our hospital from January,2018 to January,2020 were selected to collect their gastric cancer tissues and corresponding adjacent tissues during surgery;Immunohistochemical method was applied to detect the expression of PXN and PARK7 proteins in gastric cancer tissue and adjacent tissues;Kaplan-Meier survival curve and log-rank test were applied to evaluate the relationship between PXN,PARK7,and prognosis;Cox regression was applied to identify risk factors affecting the prognosis of gastric cancer patients.Results The positive expression rates of PXN and PARK7 proteins in gastric cancer tissue were significantly higher than those in adjacent tissues(P<0.05).The positive expression of PXN and PARK7 in gastric cancer tissue was related to TNM staging,differentiation degree,lymph node metastasis,and depth of infiltration(P<0.05).According to the Kaplan-Meier method,the 3-year survival rate of patients with PXN positive expression in gastric cancer tissue was lower than that of patients with negative expression(χ^(2)=5.034,P<0.05);The 3-year survival rate of patients with positive expression of PARK7 in gastric cancer tissue was lower than that of patients with negative expression(χ^(2)=4.837,P<0.05).According to Cox regression analysis,the positive expression of PXN,positive expression of PARK7,TNM staging,degree of differentiation,lymph node metastasis,and depth of infiltration were risk factors affecting the prognosis of gastric cancer patients(P<0.05).Conclusion The expression of PXN and PARK7 proteins in cancer tissue of gastric cancer patients is significantly increased,which is closely related to clinicopathological characteristics and prognosis.

关 键 词：桩蛋白 帕金森病蛋白7 免疫组织化学 胃癌 预后 

分 类 号：R735.2[医药卫生—肿瘤]