分化型甲状腺癌组织FGFR3、TRIM21表达及临床意义  

The Expression and Clinical Significance of FGFR3 and TRIM21 inDifferentiated Thyroid Cancer Tissue

作　　者：张有 范春桃 张华旭 ZHANG You;FAN Chuntao;ZHANG Huaxu(Laboratory Pathology and Blood Transfusion Department of the 943rd Hospital of the Joint Logistics SupportForce of the People’s Liberation Army,Wuwei 733000,China)

机构地区：[1]解放军联勤保障部队第943医院检验病理输血科,甘肃武威733000

出　　处：《标记免疫分析与临床》2023年第10期1716-1721,共6页Labeled Immunoassays and Clinical Medicine

基　　金：武威市科学技术局2013年度第一批科技计划项目(编号:WW130116)。

摘　　要：目的 探讨成纤维细胞生长因子受体3(FGFR3)、三结构域蛋白家族成员21(TRIM21)在分化型甲状腺癌组织中的表达及临床意义。方法 收集我院2018年5月至2020年1月期间住院手术的120例分化型甲状癌患者术中甲状腺癌组织标本及癌旁组织标本,同时整理其TNM分期、淋巴结转移等临床资料。采用免疫组织化学法检测FGFR3、TRIM21的表达;Spearman法分析分化型甲状腺癌组织FGFR3和TRIM21表达的相关性;分化型甲状腺癌组织FGFR3和TRIM21表达与患者预后的关系采用Kaplan-Meier法分析;多因素Cox回归分析分化型甲状腺癌患者预后的影响因素。结果与癌旁组织相比,分化型甲状腺癌组织中FGFR3、TRIM21蛋白的高表达率明显较高(P<0.05)。FGFR3和TRIM21蛋白的表达与TNM分期、淋巴结转移相关(P<0.05)。Spearman相关性分析显示,分化型甲状腺癌组织FGFR3和TRIM21表达具有正相关性(P<0.05)。分化型甲状腺癌组织FGFR3和TRIM21高表达患者3年生存率低于FGFR3和TRIM21低表达患者(P<0.05)。多因素Cox回归分析,结果显示FGFR3、TRIM21、TNM分期、淋巴结转移是分化型甲状腺癌患者死亡的影响因素(P<0.05)。结论 分化型甲状腺癌组织FGFR3、TRIM21表达与TNM分期、淋巴结转移等临床病理特征及预后有密切联系,检测其表达水平对判断患者预后生存情况具有重要价值。Objective To investigate the expression and clinical significance of fibroblast growth factor receptor 3(FGFR3)and tripartite motif 21(TRIM21)in differentiated thyroid cancer tissue.Methods Intraoperative thyroid cancer tissue samples and adjacent tissue samples were collected from 120 patients with differentiated thyroid cancer who underwent surgery at our hospital from May,2018 to January,2020.Clinical data,including TNM staging and lymph node metastasis were obtained for the analysis.Immunohistochemical staining was applied to detect the expression of FGFR3 and TRIM21;Spearman method was applied to analyze the correlation between the expression of FGFR3 and TRIM21 in differentiated thyroid cancer tissue;The relationship between the expression of FGFR3 and TRIM21 in differentiated thyroid cancer tissue and patient prognosis was analyzed by Kaplan-Meier method;Multivariate Cox regression was applied to analyze the prognostic factors in patients with differentiated thyroid cancer.Results Compared with adjacent tissues,the high expression rates of FGFR3 and TRIM21 proteins in differentiated thyroid cancer tissues were significantly higher(P<0.05).The expressions of FGFR3 and TRIM21 proteins were correlated with TNM staging and lymph node metastasis(P<0.05).Spearman correlation analysis showed a positive correlation between the expressions of FGFR3 and TRIM21 in differentiated thyroid cancer tissue(P<0.05).The 3-year survival rate of patients with high expressions of FGFR3 and TRIM21 in differentiated thyroid cancer tissue was lower than that of patients with low expressions of FGFR3 and TRIM21(P<0.05).Multivariate Cox regression analysis showed that FGFR3,TRIM21,TNM staging,and lymph node metastasis were the influencing factors for mortality in patients with differentiated thyroid cancer(P<0.05).Conclusion The expressions of FGFR3 and TRIM21 in differentiated thyroid cancer tissue is closely related to clinical pathological features,such as TNM staging,lymph node metastasis,and prognosis.Detecting their expression

关 键 词：分化型甲状腺癌 成纤维细胞生长因子受体3 三结构域蛋白家族成员21 临床意义 

分 类 号：R736.1[医药卫生—肿瘤]