Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice  

作　　者：Li Sun Tao Wang Baosong Chen Cui Guo Shanshan Qiao Jinghan Lin Huan Liao Huanqin Dai Bin Wang Jingzu Sun Hongwei Liu 

机构地区：[1]State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [2]Savaid Medicine School,University of Chinese Academy of Sciences,Beijing 100101,China [3]Guangxi Academy of Sciences,Nanning 530007,China

出　　处：《Food Science and Human Wellness》2024年第2期633-648,共16页食品科学与人类健康（英文）

基　　金：supported by the National key research and development program of China(2019YFA0905600);the Science and Technology Service Network Program of the Chinese Academy of Sciences(KFJ-STS-QYZD-201-5-3);the Strategic Priority Research Program(Class B)of Chinese Academy of Sciences(XDB 38020300)。

摘　　要：Sugarcane leaves-derived polyphenols(SLP)have been demonstrated to have diverse health-promoting benefits,but the mechanism of action has not been fully elucidated.This study aimed to investigate the anti-metabolic disease effects of SLP and the underlying mechanisms in mice.In the current study,we prepared the SLP mainly consisting of three flavonoid glycosides,three phenol derivatives,and two lignans including one new compound,and further demonstrated that SLP reduced body weight gain and fat accumulation,improved glucose and lipid metabolism disorders,ameliorated hepatic steatosis,and regulated short-chain fatty acids(SCFAs)production and secondary bile acids metabolism in ob/ob mice.Notably,SLP largely altered the gut microbiota composition,especially enriching the commensal bacteria Akkermansia muciniphila and Bacteroides acidifaciens.Oral gavage with the above two strains ameliorated metabolic syndrome(MetS),regulated secondary bile acid metabolism,and increased the production of SCFAs in high-fat diet(HFD)-induced obese mice.These results demonstrated that SLP could be used as a prebiotic to attenuate MetS via regulating gut microbiota composition and further activating the secondary bile acids-mediated gut-adipose axis.

关 键 词：Sugarcane leaves-derived polyphenols Metabolic syndrome Bacteroides acidifaciens Akkermansia muciniphila Secondary bile acids metabolism 

分 类 号：TS201.4[轻工技术与工程—食品科学]