Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet  

作　　者：Chengcheng Wang Xuefeng Duan Xiaoyue Li Jinyue Yang Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang 

机构地区：[1]College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China [2]Laboratory for Marine Drugs and Bioproducts,Pilot National Laboratory for Marine Science and Technology(Qingdao),Qingdao 266237,China [3]Laboratory of Nutrition Biochemistry,Department of Applied Biochemistry and Food Science,Saga University,Saga 840-8502,Japan

出　　处：《Food Science and Human Wellness》2024年第2期649-658,共10页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China(32072145)。

摘　　要：Trimethylamine N-oxide(TMAO)is a risk factor of various chronic diseases,which was produced by metabolism from precursors to trimethylamine(TMA)in gut and the oxidation from TMA in liver.The TMA generation was influenced by diet,mainly due to the rich TMAO precursors in diet.However,it was still unclear that the effects of different proportion and source of macronutrients in different dietary pattern on the production process of TMAO.Here,the generation of TMA from precursors and TMAO from TMA was determined after single oral choline chloride and intraperitoneal injection TMA,respectively,in mice fed with carbohydrates,proteins and fats in different proportion and sources.The results suggested that the generation of TMAO was increased by low non-meat protein and high fat via enhancing the production of TMAO from TMA,and decreased by plant protein and refined sugar via reducing TMA production from precursors in gut and TMAO transformation from TMA in liver.The high fat and high sugar diets accelerating the development of atherosclerosis did not increase the production of TMAO,the risk factor for atherosclerosis,which indicated that the dietary compositions rather than the elevated TMAO level might be a more key risk factor for atherosclerosis.

关 键 词：Trimethylamine N-oxide(TMAO) Trimethylamine(TMA) Dietary composition MACRONUTRIENTS Gut microbiota 

分 类 号：TS201.4[轻工技术与工程—食品科学]