不同OLGIM分期慢性胃炎患者血清COX-2、TFF2表达水平及其与幽门螺杆菌感染的相关性分析  

Expression levels of serum COX-2 and TFF2 in patients with different OLGIM stages of chronic gastritis and their correlation with Helicobacter pylori infection

作　　者：刘振北 唐军 吴婷婷[1] LIU Zhen-bei;TANG Jun;WU Ting-ting(Department of Gastroenterology,Chuzhou Integrated Traditional Chinese and Western Medicine Hospital,Chuzhou Anhui 239000,China)

机构地区：[1]滁州市中西医结合医院消化科,安徽滁州239000

出　　处：《临床和实验医学杂志》2023年第24期2596-2600,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽省中医药传承创新科研项目(编号:2022CCZD08)。

摘　　要：目的分析不同慢性胃炎肠化生分级分期评估系统(OLGIM)分期慢性胃炎患者血清环氧化酶-2(COX-2)、三叶因子2(TFF2)的表达水平及其与幽门螺杆菌(Hp)感染的相关性。方法前瞻性选取2018年1月至2022年12月滁州市中西医结合医院收治的120例慢性胃炎患者和同期进行体检的100名健康体检者(对照组)作为研究对象。根据OLGIM分期系统分析120例慢性胃炎患者OLGIM分期。分别采用酶联免疫吸附试验检测对照组与不同OLGIM分期慢性胃炎患者的血清COX-2、TFF2水平,分析OLGIM 0~Ⅱ期、OLGIMⅢ~Ⅳ期慢性胃炎患者与临床特征(性别、年龄、体重指数、病理类型、家族史和Hp感染)的关系,采用双变量Spearman相关性检验分析慢性胃炎Hp阳性与OLGIM分期和血清COX-2、TFF2的相关性,并建立多因素Logistic模型分析血清COX-2、TFF2对不同OLGIM分期Hp阳性的影响,同时分析其预测价值。结果120例OLGIM分期0、Ⅰ、Ⅱ、Ⅲ、Ⅳ期分别为10.00%、16.67%、10.00%、43.33%、20.00%。与对照组、OLGIM 0~Ⅱ期比较,OLGIMⅢ~Ⅳ期慢性胃炎的血清COX-2表达水平较高,TFF2表达水平较低,差异均有统计学意义(P<0.05)。与OLGIM 0~Ⅱ期比较,Ⅲ~Ⅳ期患者的Hp阳性率较高(79.49%vs.20.51%),差异有统计学意义(P<0.05)。多因素Logistic结果显示,COX-2、TFF2均是影响OLGIM 0~Ⅱ期、Ⅲ~Ⅳ期慢性胃炎患者Hp感染的独立危险因素(P<0.05)。慢性胃炎Hp阳性与OLGIM分期和血清COX-2均呈正相关(P<0.05),与TFF2呈负相关(P<0.05)。血清COX-2、TFF2与COX-2+TFF2在预测不同OLGIM分期慢性胃炎Hp阳性的曲线下面积(AUC)均大于0.75。结论血清COX-2、TFF2及Hp感染均与慢性胃炎OLGIM分期进展程度存在一定关联,可根据血清COX-2、TFF2表达水平的变化情况及Hp感染率判断患者的OLGIM分期情况。Objective To analyze the expression levels of serum cyclooxygenase-2(COX-2)and trefoil factor family 2(TFF2)in patients with different operative link on gastritis intestinalmetaplasia(OLGIM)stages of chronic gastritis and their correlation with Helicobacter pylori(Hp)infection.Methods A total of 120 patients with chronic gastritis admitted to Chuzhou Integrated Traditional Chinese and Western Medicine Hospital from January 2018 to December 2022 and 100 healthy subjects(control group)who underwent physical examination in the same period were selected as the research objects.A total of 120 patients with chronic gastritis were included in the OLGIM staging system to analyze their OLGIM staging.The levels of serum COX-2 and TFF2 in the control group and patients with chronic gastritis at different OLGIM stages were detected by enzyme-linked immunosorbent assay.The relationship between clinical characteristics(gender,age,body mass index,pathological type,family history,and Hp infection)and patients with OLGIM 0-Ⅱstage OLGIMⅢ-Ⅳstage.The correlation between Hp positivity in chronic gastritis and OLGIM staging,as well as serum COX-2 and TFF2 was analyzed using a bivariate Spearman correlation test.The effect of serum COX-2 and TFF2 on Hp positive in different OLGIM stages was analyzed by Multivariate Logistic model,and its predictive value was analyzed.Results A total of 120 cases of OLGIM stage 0,Ⅰ,Ⅱ,Ⅲ,Ⅳwere 10.00%,16.67%,10.00%,43.33%,20.00%.Compared with the control group and OLGIM 0-Ⅱstage,the expression level of serum COX-2 in chronic gastritis of OLGIMⅢ-Ⅳstage was higher and the expression level of TFF2 was lower,the differences were statistically significant(P<0.05).Compared with OLGIM 0-Ⅱ,the positive rate of Hp in patients with stage III-IV was higher(79.49%vs.20.51%),the difference was statistically significant(P<0.05).Multivariate Logistic results showed that COX-2 and TFF2 were independent risk factors for Hp infection in patients with OLGIM 0-ⅡandⅢ-Ⅳchronic gastritis(P<0.05).Hp po

关 键 词：慢性胃炎 OLGIM分期 环氧化酶-2 三叶因子2 幽门螺杆菌感染 相关性 

分 类 号：R573.3[医药卫生—消化系统]