精神分裂症和双相障碍患者中性粒细胞-淋巴细胞比值及血清电解质水平的比较  

Comparison of Neutrophil-Lymphocyte ratio and serum electrolyte levels between patients with different psychiatric disorders

作　　者：谢筱颖[1] 黄炜[1] 邓德金 蓝燕玲[1] 邓志旗 黎雪松[1] XIE Xiaoying;HUANG Wei;DENG Dejin(Department of Laboratory,Foshan Third People Hospital,Foshan 528041,China)

机构地区：[1]佛山市第三人民医院检验科,佛山528041

出　　处：《国际精神病学杂志》2023年第6期1303-1306,共4页Journal Of International Psychiatry

基　　金：广东省基础与应用基础研究基金项目(编号:2021A1515011735);佛山市科技局自筹项目(编号:2320001006066)。

摘　　要：目的探讨精神分裂症和双相情感障碍患者的中性粒细胞-淋巴细胞比值以及血清电解质水平与健康人的差异,为相关精神疾病的发病机制与临床诊疗研究提供参考依据。方法分别纳入自2017~2022年来在佛山市第三人民医院门诊就诊及住院治疗的符合精神分裂症和双相情感障碍诊断标准的患者各50例,并纳入50例健康体检者作为对照组。收集所有健康者以及患者治疗前的中性粒细胞计数、淋巴细胞计数、血小板计数、电解质水平(钙、钠、钾、氯、镁及磷)以及血清碳酸氢盐水平。结果精神分裂症组粒淋比水平明显高于健康对照组(3.38±2.51 vs.2.00±1.23,P<0.01)。精神分裂症组的钙水平高于健康对照组(2.39±0.13 vs.2.34±0.10,P<0.05)。精神分裂症组(0.82±0.08,P<0.01)和双相情感障碍组(0.83±0.07,P<0.01)的镁水平均低于健康对照组(0.93±0.17)。精神分裂症组(101.50±5.26,P<0.01)和双相情感障碍组(102.50±2.71,P<0.01)的氯水平均低于健康对照组(104.60±2.15)。双相情感障碍组的磷水平高于健康对照组(1.38±0.24 vs.1.21±0.15,P<0.01)。精神分裂症(25.88±2.99,P<0.01)和双相情感障碍(24.85±2.68,P<0.01)的碳酸氢盐水平高于健康对照(23.50±1.95)。精神分裂症的粒淋比最佳阈值是2.982,AUC是0.7886,灵敏度54.00%,特异度91.84%;双相情感障碍的粒淋比最佳阈值是3.319,AUC是0.5396,灵敏度16.00%,特异度95.92%。结论精神分裂症组粒淋比水平明显高于健康对照组,精神分裂症和双相情感障碍患者的电解质水平有不同程度的差异。Objective This study aimed to investigate the differences in Neutrophil-Lymphocyte ratio and serum electrolyte levels in patients with schizophrenia and bipolar disorder compared with healthy people,in order to provide a theoretical reference for the pathogenesis,diagnosis and treatment of related mental diseases.Methods This study enrolled 50 patients who met the diagnostic criteria of schizophrenia and bipolar disorder attending outpatient and inpatient treatment at the Third People's Hospital of Foshan from 2017 to 2022.And 50 healthy people were collected as controls.The pre-treatment neutrophil count,lymphocyte count,platelet count,electrolyte levels(calcium,sodium,potassium,chloride,magnesium and phosphorus)and serum carbonate levels of were collected.Results Neutrophil-Lymphocyte ratio were significantly higher in the schizophrenia groups than in the healthy controls(3.38±2.51 vs.2.00±1.23,P<0.001).Calcium levels were higher in the schizophrenia group than in the healthy controls(2.39±0.13 vs.2.34±0.10,P<0.05).Magnesium levels were lower in the schizophrenia(0.82±0.08,P<0.01)and bipolar disorder(0.83±0.07,P<0.01)groups than in the healthy control group(0.93±0.17).Chloride was lower on average in the schizophrenia(101.50±5.26,P<0.01)and bipolar disorder(102.50±2.71,P<0.01)groups than in the healthy controls(104.60±2.15).Phosphorus levels were higher in the bipolar disorder group than in the healthy controls(1.38±0.24 vs.1.21±0.15,P<0.01).Bicarbonate levels were higher in the schizophrenia(25.88±2.99,P<0.01)and bipolar disorder(24.85±2.68,P<0.01)groups than in the healthy controls(23.50±1.95).The ROC curve showed that the optimal threshold of neutrophil-Lymphocyte ratio for schizophrenia is 2.982,AUC is 0.7886,sensitivity is 54.00%,and specificity is 91.84%;the optimal threshold value of neutrophil-Lymphocyte ratio for bipolar disorder is 3.319,AUC is 0.5396,sensitivity is 16.00%,and specificity is 95.92%.Conclusion NeutrophilLymphocyte ratio was significantly higher in the schizophrenia group

关 键 词：精神分裂症 双相情感障碍 粒淋比 电解质 

分 类 号：R749.3[医药卫生—神经病学与精神病学]