高压氧联合心理干预对创伤性颅脑损伤患者负性情绪、认知功能及继发性癫痫的影响  

Effects of hyperbaric oxygen combined with psychological intervention on negative emotion,cognitive function and secondary epilepsy in patients with traumatic brain injury

作　　者：常丙林[1] 常晓赞 周艳宏[1] 张浩 CHANG Binglin;CHANG Xiaozan;ZHOU Yanhong(Neurosurgery,Anyang Regional Hospital,Puyang City,Anyang 455000,China)

机构地区：[1]濮阳市安阳地区医院神经外科,安阳455000 [2]河南省人民医院脑血管病科

出　　处：《国际精神病学杂志》2023年第6期1428-1431,共4页Journal Of International Psychiatry

摘　　要：目的探索高压氧联合心理干预对创伤性颅脑损伤(Traumatic brain injury,TBI)患者脑血流动力学、认知功能及继发性癫痫的影响。方法选取我院2019年5月~2022年2月106例TBI患者为研究对象,依据随机数字表法分为常规组和综合组。常规组53例给予依达拉奉联合神经节苷脂的常规治疗,综合组53例在常规治疗的基础上联合高压氧及心理干预治疗。对比两组认知功能,负性情绪及继发性癫痫发生情况。结果两组治疗4疗程后蒙特利尔认知评估量表、简易精神状态检查量表评分较治疗前升高,综合组高于常规组(P<0.05)。两组治疗4疗程后抑郁自评表、焦虑自评量表评分较治疗前降低,综合组低于常规组(P<0.05)。综合组随访1个月继发性癫痫发生率1.89%(1/53)低于常规组5.66%(3/53),差异无统计学显著性(P>0.05);综合组随访3个月继发性癫痫发生率3.77%(2/53)低于常规组18.87%(10/53),差异具有统计学显著性(P<0.05)。结论在常规治疗的基础上采用高压氧联合心理干预可改善TBI患者认知功能,调节负性情绪,改善继发性癫痫发生情况。Objective To explore the effects of hyperbaric oxygen combined with psychological intervention on cerebral hemodynamics,cognitive function and secondary epilepsy in patients with traumatic brain injury(TBI).Methods A total of 106 TBI patients in our hospital from May 2019 to February 2022 were selected as the study objects,and were divided into conventional group and comprehensive group according to random number table method.Both groups were given conventional treatment,53 cases in the conventional group were given Edaravone combined with ganglioside,and 53 cases in the comprehensive group were combined with hyperbaric oxygen and psychological intervention.Cognitive function,negative emotion and secondary epilepsy were compared between the two groups.Results After 4 courses of treatment,the scores of Montreal Cognitive Assessment Scale(MoCA)and Simple Mental State Examination Scale(MMSE)in both groups were higher than those before treatment,and those in comprehensive group were higher than those in conventional group(P<0.05).After 4 courses of treatment,the scores of self-rating depression scale(SDS)and self-rating Anxiety Scale(SAS)in both groups were lower than those before treatment,and those in comprehensive group were lower than those in conventional group(P<0.05).The incidence of secondary epilepsy in the comprehensive group was 1.89%(1/53)lower than that in the conventional group(5.66%(3/53)after 1 month follow-up,with no difference(P>0.05).After 3 months of follow-up,the incidence of secondary epilepsy in the comprehensive group was 3.77%(2/53)lower than that in the conventional group18.87%(10/53)(P<0.05).Conclusion Hyperbaric oxygen combined with psychological intervention can improve the cognitive function of TBI patients,regulate negative emotions and improve the occurrence of secondary epilepsy.

关 键 词：高压氧 心理干预 创伤性颅脑损伤 负性情绪 

分 类 号：R749.05[医药卫生—神经病学与精神病学]