产后抑郁与人新饱食分子蛋白1、瘦素、胃饥饿素的相关性  

The relationship between postpartum depression and new satiating molecules protein-1,leptin and ghrelin

作　　者：张玉娟 孙芳 ZHANG Yujuan;SUN Fang(Obstetrics and Gynecology Department,Xuzhou Central Hospital,Xuzhou 221009,China)

机构地区：[1]徐州中心医院妇产科,徐州221009

出　　处：《国际精神病学杂志》2023年第6期1439-1441,共3页Journal Of International Psychiatry

摘　　要：目的 探讨产后抑郁与人新饱食分子蛋白1(Nesfatin-1)、瘦素(Leptin,LP)、胃饥饿素(Ghrelin)的相关性。方法 本研究对象为2021年5月~2023年5月间收治的84例产妇,采用爱丁堡产后抑郁量表(Edinburgh postnatal depression scale,EPDS)进行产后抑郁评估,根据评估结果设为产后抑郁组以及无产后抑郁组。检测并比较两组患者血清Nesfatin-1、LP、Ghrelin水平,分析产后抑郁组EPDS评分与上述指标的相关性,采用受试者工作特征曲线(receiver operating characteristic curve,ROC)分析上述指标对产后抑郁的预测价值。结果 84例产妇产后抑郁28例,抑郁率33.33%;产后抑郁组血清LP、Ghrelin水平显著低于无产后抑郁组,Nesfatin-1水平显著高于无产后抑郁组,(P<0.05);产后抑郁组EPDS评分与血清Ghrelin、LP水平具有负相关关系,与Nesfatin-1水平具有正相关关系(P<0.05);血清Nesfatin-1、LP、Ghrelin预测产后抑郁AUC分别为0.839、0.738、0.770,具有较高的特异性与敏感性。结论 产后抑郁发生率较高,其发生与发展可能与血清Nesfatin-1、LP、Ghrelin水平有关,且上述指标对产后抑郁具有一定的预测价值。Objective To explore the correlation between postpartum depression and new satiating molecule protein 1(Nesfatin-1),Leptin(LP)and Ghrelin.Methods Eighty-four pregnant and postpartum women from May 2021 to May 2023 were selected as the study subjects.The postpartum depression were evaluated using the Edinburgh Postpartum Depression Scale(EPDS).They were divided into the postpartum depression group and non postpartum depression group according the evaluation results.Serum levels of Nesfatin-1,LP and Ghrelin were detected and compared between the two groups,and the correlation between EPDS score and the above indicators in the postpartum depression group was analyzed.receiver operating characteristic curve was adopted.ROC)to analyze the predictive value of the above indicators for postpartum depression.Results Among 84 pregnant and postpartum women,28 cases had postpartum depression,with a depression rate of 33.33%.The levels of serum Ghrelin and LP in postpartum depression group were significantly lower than those in no postpartum depression group,and the level of Nesfatin-1 was significantly higher than that in no postpartum depression group(P<0.05).EPDS score in postpartum depression group was negatively correlated with serum Ghrelin and LP levels,and positively correlated with Nesfatin-1 levels(P<0.05).Serum Nesfatin-1,LP and Ghrelin predicted the AUC of postpartum depression to be 0.839,0.738 and 0.770,respectively,with high specificity and sensitivity.Conclusion The incidence of postpartum depression is high,and its occurrence and development may be related to the levels of serum Nesfatin-1,LP and Ghrelin,which has a certain predictive value for postpartum depression.

关 键 词：产后抑郁 人新饱食分子蛋白1 瘦素 胃饥饿素 

分 类 号：R749.4[医药卫生—神经病学与精神病学]