多囊卵巢综合征患者心理状况和生活质量的相关性  

Correlation analysis of psychological status and quality of life in polycystic ovary syndrome

作　　者：金志华 周加敏 陈倩玉 许波群[1,3] JIN Zhihua;ZHOU Jiamin;CHEN Qianyu(Department of gynecology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学第二附属医院妇科,南京211166 [2]南京市江宁区妇幼保键计划生育服务中心妇女保键科 [3]南京医科大学附属逸夫医院妇科

出　　处：《国际精神病学杂志》2023年第6期1445-1449,共5页Journal Of International Psychiatry

基　　金：国家自然科学基金项目(编号:81873820)。

摘　　要：目的研究影响多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)患者心理健康和生活质量的相关因素。方法选取2020年05月~2022年06月在南京逸夫医院妇科门诊就诊的PCOS患者77例(PCOS组),并选择同期体检的49例健康女性(对照组)。测量生化指标、填写临床资料问卷、贝克抑郁量表(Beck Depression Inventory-II,BDI-II)、广泛焦虑量表(Generalized Anxiety Disorder-7,GAD-7)、PCOS特异性生活质量量表(PCOS-specific QoL scale,PCOSQ)。通过Spearman相关性分析和回归分析,研究PCOS患者心理健康和生活质量的相关因素。结果PCOS组较对照组情绪障碍发病率增高(OR=3.66,P<0.05)。PCOS患者的生活质量与游离睾酮指数(free androgen index,FAI)、体质指数(body mass index,BMI)、抑郁评分、焦虑评分成负相关(P<0.05);多元线性回归显示游离雄激素指数(FAI)、抑郁评分是PCOS患者生活质量的影响因素(P<0.05)。FAI联合甘油三酯(Triglycerides,TG)预测情绪障碍的ROC曲线下面积(AUC)为0.741(P<0.05)。结论PCOS患者情绪障碍的发病率较高,游离雄激素过多、心理健康是影响生活质量的主要因素,FAI联合TG可作为早期情绪障碍的预警指标。Objective To study factors associated with psychological health and quality of life(QoL)in women with Polycystic Ovary Syndrome(PCOS).Methods 77 PCOS patients from Nanjing Yifu Hospital and 49 healthy women as controls were included.Biochemical indicators were measured,clinical data questionnaires were filled out,and the Beck Depression Inventory-II(BDI-II),Generalized Anxiety Disorder-7(GAD-7),and PCOS-specific QoL scale(PCOSQ)were used.Differences between groups were compared,and Spearman correlation analysis was conducted.Results The PCOS group had a higher incidence of emotional disorders compared to the control group(odds ratio:3.66,P<0.05).Overall QoL negatively correlated with free androgen index(FAI),body mass index(BMI),and depression-anxiety scores(P<0.05).Multiple linear regression showed that FAI and depression scores influenced overall QoL in PCOS(P<0.05).The area under the ROC curve(AUC)of FAI combined with Triglycerides(TG)for predicting emotional disorders was 0.741(P<0.05).Conclusion Emotional disorders are more prevalent in PCOS patients,and excess biochemical androgens and emotional disorders significantly impact QoL.FAI combined with TG can serve as an early indicator for emotional disorders.

关 键 词：多囊卵巢综合征 抑郁 焦虑 生活质量 PCOSQ 

分 类 号：R749.99[医药卫生—神经病学与精神病学]